CAJ | 학술논문

目的：探讨急性髓系白血病患者化疗前给予口腔治疗对化疗期间口腔黏膜炎发生率及炎症程度的影响,为临床造血系统恶性肿瘤患者化疗前口腔治疗效果提供初步依据。方法74例患有急性髓系白血病的患者根据患者是否愿意化疗前接受口腔治疗,分为口腔治疗+化疗组和化疗组,口腔治疗+化疗组在化疗前给予全面的口腔检查以及对存在问题进行处理,化疗组则不给予任何口腔治疗。评价和记录口腔黏膜炎的发生率及程度。采用卡方检验及Mann-Whitney U检验,比较两组间差异。结果口腔治疗+化疗组的口腔黏膜炎发生率要小于化疗组(χ2=5.659,P=0.017),炎症程度也低于化疗组(U=0,P=0)。结论化疗前口腔治疗有利于减低急性髓系细胞患者化疗期间口腔黏膜炎的发生率,减轻口腔黏膜炎的炎症程度,具有重要的临床意义。
목적：탐토급성수계백혈병환자화료전급여구강치료대화료기간구강점막염발생솔급염증정도적영향,위림상조혈계통악성종류환자화료전구강치료효과제공초보의거。방법74례환유급성수계백혈병적환자근거환자시부원의화료전접수구강치료,분위구강치료+화료조화화료조,구강치료+화료조재화료전급여전면적구강검사이급대존재문제진행처리,화료조칙불급여임하구강치료。평개화기록구강점막염적발생솔급정도。채용잡방검험급Mann-Whitney U검험,비교량조간차이。결과구강치료+화료조적구강점막염발생솔요소우화료조(χ2=5.659,P=0.017),염증정도야저우화료조(U=0,P=0)。결론화료전구강치료유리우감저급성수계세포환자화료기간구강점막염적발생솔,감경구강점막염적염증정도,구유중요적림상의의。
Objective To observed the effect of oral treatments before chemotherapy on the incidence and the degree of inflammation of oral mucositis of patients with acute myeloid leukemia (AML) during the chemotherapeutic period. Provide preliminary evidence for clinical effect of oral intervention before chemotherapy on patients with hematopoietic system malignant tumor. Methods Seventy-four patients with AML were divided into two groups depend on whether they want to receive oral treatments before chemotherapy. Oral treatments plus chemotherapy group received comprehensive oral examinations and treatments prechemotherapy. The chemotherapy group was not given any oral treatment. Evaluated and recorded the incidence and degree of oral mucositis. Chi square test and Mann-Whitney U were used to compare the difference between the two groups. Results The incidence of oral mucositis of the oral treatments plus chemotherapy group was less than the chemotherapy group (χ2=5.659,P=0.017), the degree of inflammation was also lower than that of the chemotherapy group (U=0, P=0). Conclusion Oral treatments before chemotherapy can reduce the incidence and the degree of inflammation of oral mucositis of patients with AML during the chemotherapeutic period. It has important clinical significance.