CAJ | 학술논문

背景阿片类药物是临床癌痛治疗常用药物之一,但其疗效、安全性个体差异较大,常需逐渐调整剂量以获最佳用药剂量. 目的探讨阿片类药物滴定及转换在癌痛治疗中的应用前景,为安全有效的镇痛提供依据. 内容比较不同的阿片类药物在癌痛治疗过程中滴定、转换及爆发痛抑制应用的特点,提出存在的难题. 趋向阿片类药物滴定在癌痛治疗中的应用还需进行更多的研究,以利于临床推广.
배경 아편류약물시림상암통치료상용약물지일,단기료효、안전성개체차이교대,상수축점조정제량이획최가용약제량. 목적 탐토아편류약물적정급전환재암통치료중적응용전경,위안전유효적진통제공의거. 내용 비교불동적아편류약물재암통치료과정중적정、전환급폭발통억제응용적특점,제출존재적난제. 추향 아편류약물적정재암통치료중적응용환수진행경다적연구,이리우림상추엄.
Background Opioid drug is a common medication used to treat cancer-related pain in clinic.However,its efficiency and safety present significant individual difference.So it's dosage oftern needs to be adjust gradually to get optimal dosage.Objective To summarized the application of dosage titration and rotation of opioids in cancer pain treatment for safe and effective analgesia.Content We compared the properties of different opioids on titration,rotation and the suppression of breakthrough pain during the treatment of cancer pain,and proposed the problem of their application.Trend Further studies are needed for the dosage titration and rotation of opioids in the treatment of cancer pain,in order to facilitate clinical practices.