CAJ | 학술논문

目的：观察和分析氨溴特罗和孟鲁司特联合治疗小儿咳嗦变异型哮喘的临床治疗效果，旨在为临床用药提供有效依据。方法选取2012年12月～2014年12月间我院收治的100例咳嗽变异性哮喘患儿作为临床研究对象，使用随机分组法将其随机分为研究组（n=50例）和对照组（n=50例）。对照组患儿单纯采用氨溴特罗进行治疗，研究组患儿在对照组的治疗基础上加用孟鲁司特联合进行治疗。观察和记录两组患者治疗的总有效率及临床症状缓解、消失时间，并进行对比分析。结果研究组患儿的咳嗽缓解时间和咳嗽消失时间均明显低于对照组，P ＜0.05。研究组患儿治疗的总有效率（96.0%）高于对照组（74.0%），P ＜0.05。结论氨溴特罗联合孟鲁司特治疗小儿咳嗽变异性哮喘的疗效显著。
목적：관찰화분석안추특라화맹로사특연합치료소인해색변이형효천적림상치료효과，지재위림상용약제공유효의거。방법선취2012년12월～2014년12월간아원수치적100례해수변이성효천환인작위림상연구대상，사용수궤분조법장기수궤분위연구조（n=50례）화대조조（n=50례）。대조조환인단순채용안추특라진행치료，연구조환인재대조조적치료기출상가용맹로사특연합진행치료。관찰화기록량조환자치료적총유효솔급림상증상완해、소실시간，병진행대비분석。결과연구조환인적해수완해시간화해수소실시간균명현저우대조조，P ＜0.05。연구조환인치료적총유효솔（96.0%）고우대조조（74.0%），P ＜0.05。결론안추특라연합맹로사특치료소인해수변이성효천적료효현저。
Objective To observe and analyze the clinical treatment effects of children with cough variant asthma cured by ambroxol combined with <br> montelukast. Methods 100 children who suffered from the cough variant asthma and who accepted treatments in our hospital from December, 2012 to December, 2014 were taken as the research objects, and these patients were randomly divided into the control group and the study group, with 50 patients in each group. In the control group, they were treated with the ambroxol single while in the study group, on the basis of the treatment in the control group, they were treated with the montelukast. Then, the total effective rate and clinical symptoms, the disappearance time of these two groups of patients were compared and recorded. Results The cough remission time and the time of cough disappearance in the study group were significantly lower than that in the control group (P<0.05)and the differences had the statistical significance. In addition, the total effective rate of treatment in the study group (96%) was significantly higher than that in the control group (74%), P<0.05, and the differences had the statistical significance. Conclusion The clinical effects of ambroxol combined with montelukast in treatment of children with cough variant asthma are significant.