中国血液流变学杂志
中國血液流變學雜誌
중국혈액류변학잡지
CHINESE JOURNAL OF HEMORHEOLOGY
2015年
1期
29-32
,共4页
高血压伴脑出血%颈动脉内中膜厚度%生物标志物%受试者工作特征曲线(ROC曲线)%有价值指标
高血壓伴腦齣血%頸動脈內中膜厚度%生物標誌物%受試者工作特徵麯線(ROC麯線)%有價值指標
고혈압반뇌출혈%경동맥내중막후도%생물표지물%수시자공작특정곡선(ROC곡선)%유개치지표
hypertension cerebral hemorrhage%intima-media thickness(IMT)%biomarker%receiver operating characteristic curve(ROC curve)%valuable index
目的：探讨高血压伴脑出血患者血浆生物标志物水平的临床意义。方法采用生物化学分析和放射免疫分析186例高血压伴脑出血、167例单纯高血压、86例单纯高血压血压控制正常患者和65名正常对照组血浆LP(a)、HCY、D-D和CRP水平并进行对比性分析。利用受试者工作特征曲线（ROC曲线）评价生物标志物LP(a)、HCY、D-D和CRP预测单纯高血压向高血压伴脑出血转化时的性能评估价值。结果高血压伴脑出血患者血浆LP(a)、HCY和CRP水平较之单纯高血压明显增高，差异有统计学意义（P均＜0.01），血浆D-D水平差异无统计学意义（P＞0.05），并随颈动脉狭窄率的增加而增高。ROC曲线显示：HCY和CRP具有单纯高血压向高压伴脑出血转化时的诊断价值，并以HCY为最佳。结论血浆HCY和CRP水平是评价单纯高血压向高血压伴脑出血转化时的有价值指标。
目的：探討高血壓伴腦齣血患者血漿生物標誌物水平的臨床意義。方法採用生物化學分析和放射免疫分析186例高血壓伴腦齣血、167例單純高血壓、86例單純高血壓血壓控製正常患者和65名正常對照組血漿LP(a)、HCY、D-D和CRP水平併進行對比性分析。利用受試者工作特徵麯線（ROC麯線）評價生物標誌物LP(a)、HCY、D-D和CRP預測單純高血壓嚮高血壓伴腦齣血轉化時的性能評估價值。結果高血壓伴腦齣血患者血漿LP(a)、HCY和CRP水平較之單純高血壓明顯增高，差異有統計學意義（P均＜0.01），血漿D-D水平差異無統計學意義（P＞0.05），併隨頸動脈狹窄率的增加而增高。ROC麯線顯示：HCY和CRP具有單純高血壓嚮高壓伴腦齣血轉化時的診斷價值，併以HCY為最佳。結論血漿HCY和CRP水平是評價單純高血壓嚮高血壓伴腦齣血轉化時的有價值指標。
목적：탐토고혈압반뇌출혈환자혈장생물표지물수평적림상의의。방법채용생물화학분석화방사면역분석186례고혈압반뇌출혈、167례단순고혈압、86례단순고혈압혈압공제정상환자화65명정상대조조혈장LP(a)、HCY、D-D화CRP수평병진행대비성분석。이용수시자공작특정곡선（ROC곡선）평개생물표지물LP(a)、HCY、D-D화CRP예측단순고혈압향고혈압반뇌출혈전화시적성능평고개치。결과고혈압반뇌출혈환자혈장LP(a)、HCY화CRP수평교지단순고혈압명현증고，차이유통계학의의（P균＜0.01），혈장D-D수평차이무통계학의의（P＞0.05），병수경동맥협착솔적증가이증고。ROC곡선현시：HCY화CRP구유단순고혈압향고압반뇌출혈전화시적진단개치，병이HCY위최가。결론혈장HCY화CRP수평시평개단순고혈압향고혈압반뇌출혈전화시적유개치지표。
ObjectiveTo explore the clinical signifi cance of plasma biomarkers levels in the patients with hypertensive cerebral hemorrhage.Methods Plasma LP(a), HCY, D-D and CRP levels were determined in 186 patients with hypertensive cerebral hemorrhage, 167 patients with simple hypertension, 86 patients with simple hypertension (blood pressure normal with medication) and 65 controls by biochemistry and radioimmunoassay and compared analysis was done as well. The receiver operating characteristic (ROC) curve was plotted to analyze LP(a), HCY, D-D and CRP as a prognostic clinical value indicator of simple hypertension transfer to hypertensive cerebral hemorrhage.Results Plasma LP(a), HCY and CRP levels in patients with hypertensive cerebral hemorrhage were significantly higher than those in patients with simple hypertension (P<0.01), but the D-D level was not signifi cantly different (P>0.05), and increased with IMT severity. ROC curve also showed that two indexes had diagnosis value in simple hypertension transfered to hypertensive cerebral hemorrhage and HCY was excellent.Conclusion Plasma HCY and CRP levels were valuable indexes to predict simple hypertension transfer to hypertension cerebral hemorrhage.
