CAJ | 학술논문

目的探讨CXC趋化因子受体-4(CXCR4)和生存素(Survivin)蛋白在非小细胞肺癌中的表达及其临床意义.方法应用免疫组织化学法检测64例肺癌组织标本及癌旁组织CXCR4和Survivin的表达,分析其表达与临床病理参数及预后的关系.结果 64例肺癌组织中有41例CXCR4蛋白阳性表达和43例Survivin蛋白阳性表达,阳性表达率分别为64.1％和67.2％,正常肺组织呈阴性表达(P＜0.01);CXCR4和Survivin蛋白表达与TNM分期、淋巴结转移和组织分化程度有关(P＜0.05);肺癌中CXCR4和Survivin蛋白表达呈正相关(r=0.448 P＜0.05).结论 CXCR4和Survivin蛋白在肺癌中高表达,两者在肺癌的发展中相互促进.
목적 탐토CXC추화인자수체-4(CXCR4)화생존소(Survivin)단백재비소세포폐암중적표체급기림상의의.방법 응용면역조직화학법검측64례폐암조직표본급암방조직CXCR4화Survivin적표체,분석기표체여림상병리삼수급예후적관계.결과 64례폐암조직중유41례CXCR4단백양성표체화43례Survivin단백양성표체,양성표체솔분별위64.1％화67.2％,정상폐조직정음성표체(P＜0.01);CXCR4화Survivin단백표체여TNM분기、림파결전이화조직분화정도유관(P＜0.05);폐암중CXCR4화Survivin단백표체정정상관(r=0.448 P＜0.05).결론 CXCR4화Survivin단백재폐암중고표체,량자재폐암적발전중상호촉진.
Objective To investigate the expression of CXC chemokine receptor-4 (CXCR4) and Survivin in non-small lung cancer and the mechanism.Methods Immunohistochemical streptavidin-perosidase technique was used to detect the expression of CXCR4 and Survivin in 64 cases of non-small lung cancer tissues.Subsequently,the associations between CXCR4 expression,Survivin expression,CXCR4/Survivin coexpression and clinicopathologic factors were assessed,and survival analyses were performed.Results In total,41 (64.1％) patients expressed CXCR4,43 (67.2％) expressed Survivin,and 34 (82.9％) coexpressed CXCR4 and Survivin.Significant association between CXCR4 and Survivin expression was observed (r =0.448) in non-small lung cancer tissues.The expression of CXCR4 was correlated with tumor differentiation,TNM stage and lymph node metastasis (P ＜ 0.05),but not with histological types,gender and age (P ＞ 0.05).The positive rate of Survivin was correlated with differentiation,clinical staging and lymph node metastasis (P ＜ 0.05),but not with gender,age and histological types (P ＞ 0.05).Conclusion The high expression of CXCR-4 and Survivin may contribute to metastasis,invasion and lymph node metastasis of non-small lung cancer.