中国药物与临床
中國藥物與臨床
중국약물여림상
CHINESE REMEDIES & CLINICS
2015年
8期
1077-1079
,共3页
安钠咖%体重%大鼠%学习能力
安鈉咖%體重%大鼠%學習能力
안납가%체중%대서%학습능력
Sodium benzoate%Weight%Rat%Learning ability
目的：观察腹腔注射安钠咖对大鼠体质量及空间学习和记忆巩固能力的影响。方法27只雄性SD大鼠随机分为3组：对照组、安钠咖小剂量组及安钠咖大剂量组，隔1 d于腹腔注射药物前测量并记录大鼠体质量。药物注射结束后，应用Morris水迷宫评定大鼠空间学习及记忆巩固能力。结果安钠咖大剂量组大鼠平均体质量与对照组比较，差异有统计学意义（P＜0.05）；而安钠咖小剂量组与对照组、安钠咖大剂量组大鼠体质量比较，差异均无统计学意义（P＞0.05）。在Morris水迷宫定位航行试验中，安钠咖大剂量组逃避潜伏期与对照组及安钠咖小剂量组相比，差异有统计学意义（P＜0.05）；而对照组与安钠咖小剂量组比较平均逃避潜伏期在各训练日差异均无统计学意义（P＞0.05）。结论大剂量安钠咖使大鼠体质量增加缓慢，并可损害大鼠空间学习和记忆巩固能力。
目的：觀察腹腔註射安鈉咖對大鼠體質量及空間學習和記憶鞏固能力的影響。方法27隻雄性SD大鼠隨機分為3組：對照組、安鈉咖小劑量組及安鈉咖大劑量組，隔1 d于腹腔註射藥物前測量併記錄大鼠體質量。藥物註射結束後，應用Morris水迷宮評定大鼠空間學習及記憶鞏固能力。結果安鈉咖大劑量組大鼠平均體質量與對照組比較，差異有統計學意義（P＜0.05）；而安鈉咖小劑量組與對照組、安鈉咖大劑量組大鼠體質量比較，差異均無統計學意義（P＞0.05）。在Morris水迷宮定位航行試驗中，安鈉咖大劑量組逃避潛伏期與對照組及安鈉咖小劑量組相比，差異有統計學意義（P＜0.05）；而對照組與安鈉咖小劑量組比較平均逃避潛伏期在各訓練日差異均無統計學意義（P＞0.05）。結論大劑量安鈉咖使大鼠體質量增加緩慢，併可損害大鼠空間學習和記憶鞏固能力。
목적：관찰복강주사안납가대대서체질량급공간학습화기억공고능력적영향。방법27지웅성SD대서수궤분위3조：대조조、안납가소제량조급안납가대제량조，격1 d우복강주사약물전측량병기록대서체질량。약물주사결속후，응용Morris수미궁평정대서공간학습급기억공고능력。결과안납가대제량조대서평균체질량여대조조비교，차이유통계학의의（P＜0.05）；이안납가소제량조여대조조、안납가대제량조대서체질량비교，차이균무통계학의의（P＞0.05）。재Morris수미궁정위항행시험중，안납가대제량조도피잠복기여대조조급안납가소제량조상비，차이유통계학의의（P＜0.05）；이대조조여안납가소제량조비교평균도피잠복기재각훈련일차이균무통계학의의（P＞0.05）。결론대제량안납가사대서체질량증가완만，병가손해대서공간학습화기억공고능력。
Objective To investigate the effects of intraperitoneal injection of sodium benzoate on the weight and spatial learning and memory consolidation in rats. Methods Twenty-seven male SD rats were randomly divided into three groups: the control group, sodium benzoate low-dose group and sodium benzoate high-dose group. The weight of rats were measured and recorded with an interval one day before the drugs were intraperitoneally injected. After the drug injection, Morris water maze was used to assess the spatial learning and memory consolidation of rats. Results There was statistically significant difference in the average weight of rats between the sodium benzoate high-dose group and the control group (P<0.05). However, no statistically significant difference was found in the weight of rats between the sodium benzoate low-dose group and the control group or the sodium benzoate high-dose group (P>0.05). In the navigation test of Morris water maze, there was statistically significant difference in the escape latency of rats between the sodium benzoate high-dose group and the control group or the sodium benzoate low-dose group (P<0.05). No statistically significant difference was found in the average escape latency at every training day between the control group and the sodium benzoate low-dose group (P>0.05). Conclusion Using high-dose of sodium benzoate in this experiment can slow weight gain, and decrease spatial learning and memory consolidation in rats.
