CAJ | 학술논문

背景:采用何种材料作为肩袖补片是最安全的或最有效的仍没有共识或明确的指南.目的:综述肩袖补片材料的基础研究、临床应用现状及前景.方法:利用计算机检索EMbase、Medline、PubMed、OVID、Cochrane Library、Springerlink、万方数据库、中国知识资源总库及维普数据库,查阅国内外肩袖补片的基础研究与治疗肩袖撕裂的相关文献,并进行总结归纳.结果与结论:肩袖补片类型可分成肌腱补片、不可降解肩袖补片、细胞外基质肩袖补片及人工合成可降解型肩袖补片 4 类.肌腱补片、不可降解补片可提供相对更好的机械强度,但肌腱补片面临术后免疫排斥反应、感染风险增加、不能恢复腱骨结合点的正常结构等问题,而不可降解补片的长期安全性尚不确定;细胞外基质肩袖补片强度相对较低,肩袖修复失败概率高;人工合成可降解型肩袖补片具有相对较强的机械强度,体内长期存留的安全性较高,但生物活性细胞的迁移、补片降解速率的调控及酸性降解物的抑制是目前需要研究的难题.
배경:채용하충재료작위견수보편시최안전적혹최유효적잉몰유공식혹명학적지남.목적:종술견수보편재료적기출연구、림상응용현상급전경.방법:이용계산궤검색EMbase、Medline、PubMed、OVID、Cochrane Library、Springerlink、만방수거고、중국지식자원총고급유보수거고,사열국내외견수보편적기출연구여치료견수시렬적상관문헌,병진행총결귀납.결과여결론:견수보편류형가분성기건보편、불가강해견수보편、세포외기질견수보편급인공합성가강해형견수보편 4 류.기건보편、불가강해보편가제공상대경호적궤계강도,단기건보편면림술후면역배척반응、감염풍험증가、불능회복건골결합점적정상결구등문제,이불가강해보편적장기안전성상불학정;세포외기질견수보편강도상대교저,견수수복실패개솔고;인공합성가강해형견수보편구유상대교강적궤계강도,체내장기존류적안전성교고,단생물활성세포적천이、보편강해속솔적조공급산성강해물적억제시목전수요연구적난제.
BACKGROUND:It is unclearwhat kind of material for rotator cuff repair augmentation is the safest or most effective. OBJECTIVE:To review the basic research, clinical application and prospects of materials for rotator cuff repair augmentation. METHODS:Eligible studies were identified from electronic databases including EMbase, Medline, PubMed, OVID, Cochrane Library, Springerlink, CNKI, WanFang, and VIP. RESULTS AND CONCLUSION:There are four kinds of patches used for rotator cuff augmentation: tendon patches, non-degradable patches, extracelular matrix-based patches and degradable synthetic patches. Tendon patches have good mechanical strength, but postoperative foreign body reactions and increasing risk of infection and unable to recover the normal structure are problems to be solved. Non-degradable patches also have good mechanical strength, but the long-term safety is unclear. Extracelular matrix-based patches remain a lower mechanical strength and have a higher failure rate. Degradable synthetic patches are proposed to overcome these previous issues by combining wel-adjusted mechanical properties with biological additives and minimize risk of infection by completely absorbing in a time-dependent manner. However, migration of bioactive cels, regulation of degradation rate and suppression of acidic degradation products is are existing problems to be solved.