中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2015年
30期
4855-4859
,共5页
生物材料%材料相容性%几丁糖%透明质酸钠%产科%粘连%剖宫产
生物材料%材料相容性%幾丁糖%透明質痠鈉%產科%粘連%剖宮產
생물재료%재료상용성%궤정당%투명질산납%산과%점련%부궁산
背景:几丁糖和透明质酸钠是目前临床常用的预防粘连材料,但目前关于二者在产科患者中预防粘连的相关报道相对较少.目的:观察几丁糖和透明质酸钠在产科患者中的防粘连效果.方法:纳入180例剖宫产妇,年龄23-39岁,按照治疗方法分为对照组、几丁糖组、透明质酸钠组,每组60例,对照组剖宫产后常规关闭腹腔,几丁糖组、透明质酸钠组剖宫产后关闭腹腔前,在子宫手术切口表面及手术部位附近肠管和腹膜分别涂抹几丁糖与透明质酸钠.术后1 d,检测3组血清白细胞介素6、白细胞介素10、肿瘤坏死因子α及C-反应蛋白水平;随访1个月,观察3组术后粘连及并发症发生情况.结果与结论:几丁糖组、透明质酸钠组粘连发生情况及粘连发生率均低于对照组(P < 0.05),血清白细胞介素6、白细胞介素10、肿瘤坏死因子α及C-反应蛋白水平均低于对照组(P < 0.05),术后感染、出血、疼痛等的并发症发生率均低于对照组(P < 0.05);几丁糖组与透明质酸钠组粘连发生情况、血清指标水平及并发症发生情况比较差异均无显著性意义.表明几丁糖和透明质酸钠均可有效抑制剖宫产术后的粘连及炎症反应,减少并发症的发生.
揹景:幾丁糖和透明質痠鈉是目前臨床常用的預防粘連材料,但目前關于二者在產科患者中預防粘連的相關報道相對較少.目的:觀察幾丁糖和透明質痠鈉在產科患者中的防粘連效果.方法:納入180例剖宮產婦,年齡23-39歲,按照治療方法分為對照組、幾丁糖組、透明質痠鈉組,每組60例,對照組剖宮產後常規關閉腹腔,幾丁糖組、透明質痠鈉組剖宮產後關閉腹腔前,在子宮手術切口錶麵及手術部位附近腸管和腹膜分彆塗抹幾丁糖與透明質痠鈉.術後1 d,檢測3組血清白細胞介素6、白細胞介素10、腫瘤壞死因子α及C-反應蛋白水平;隨訪1箇月,觀察3組術後粘連及併髮癥髮生情況.結果與結論:幾丁糖組、透明質痠鈉組粘連髮生情況及粘連髮生率均低于對照組(P < 0.05),血清白細胞介素6、白細胞介素10、腫瘤壞死因子α及C-反應蛋白水平均低于對照組(P < 0.05),術後感染、齣血、疼痛等的併髮癥髮生率均低于對照組(P < 0.05);幾丁糖組與透明質痠鈉組粘連髮生情況、血清指標水平及併髮癥髮生情況比較差異均無顯著性意義.錶明幾丁糖和透明質痠鈉均可有效抑製剖宮產術後的粘連及炎癥反應,減少併髮癥的髮生.
배경:궤정당화투명질산납시목전림상상용적예방점련재료,단목전관우이자재산과환자중예방점련적상관보도상대교소.목적:관찰궤정당화투명질산납재산과환자중적방점련효과.방법:납입180례부궁산부,년령23-39세,안조치료방법분위대조조、궤정당조、투명질산납조,매조60례,대조조부궁산후상규관폐복강,궤정당조、투명질산납조부궁산후관폐복강전,재자궁수술절구표면급수술부위부근장관화복막분별도말궤정당여투명질산납.술후1 d,검측3조혈청백세포개소6、백세포개소10、종류배사인자α급C-반응단백수평;수방1개월,관찰3조술후점련급병발증발생정황.결과여결론:궤정당조、투명질산납조점련발생정황급점련발생솔균저우대조조(P < 0.05),혈청백세포개소6、백세포개소10、종류배사인자α급C-반응단백수평균저우대조조(P < 0.05),술후감염、출혈、동통등적병발증발생솔균저우대조조(P < 0.05);궤정당조여투명질산납조점련발생정황、혈청지표수평급병발증발생정황비교차이균무현저성의의.표명궤정당화투명질산납균가유효억제부궁산술후적점련급염증반응,감소병발증적발생.
BACKGROUND:Chitosan and sodium hyaluronate are two kinds of anti-adhesion materials commonly used, but there are relatively few reports on their anti-adhesion effects in obstetrics patients. OBJECTIVE:To explore the anti-adhesion effects of chitosan and sodium hyaluronate in obstetric patients. METHODS:Totaly 180 cesarean section patients, aged 23-39 years, were equaly divided into control group, chitosan group and sodium hyaluronate group according to treatment methods. Patients in the control group were given the routine cesarean section; patients in the chitosan and sodium hyaluronate group were respectively given local smearing of chitosan and hyaluronate sodium. At 1 day after operation, the levels of serum interleukin-6, interleukin-10, tumor necrosis factor-α and C-reactive protein were determined in the three groups. Then, the patients were folowed up for 1 month to observe the occurrence of postoperative adhesion and complications. RESULTS AND CONCLUSION:The incidence rate of postoperative adhesions was lower in the chitosan and sodium hyaluronate groups than the control group (P < 0.05). The levels of serum interleukin-6, interleukin-10, tumor necrosis factor-α and C-reactive protein were also lower in the chitosan and sodium hyaluronate groups than the control group (P < 0.05). In addition, the incidence rates of postoperative infection, bleeding and pain were lower in the chitosan and sodium hyaluronate groups than the control group (P < 0.05). However, there was no difference between the chitosan and sodium hyaluronate groups. These findings indicate that the chitosan and sodium hyaluronate are both effective against postoperative adhesions in cesarean section patients, and reduce the incidence of complications.
