中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
8期
1979-1982
,共4页
胃癌%TET1%预后
胃癌%TET1%預後
위암%TET1%예후
Gastric cancer%Ten-eleven translocation 1%Prognosis
目的 观察胃癌组织和癌旁组织中的TET1、TET2、TET3蛋白表达水平,探讨三者相关性及临床意义.方法 通过免疫组织化学方法检测100例胃癌患者的肿瘸组织和癌旁组织中TET1、TET2、TET3蛋白表达,分析其与临床病理特征和预后的相关性.结果 胃癌组织中TET1、TET2表达水平为2.45±0.29、4.66±0.25,显著低于癌旁组织(6.04±0.10、5.89 ±0.09),而TET3表达水平(7.84±0.17)显著高于癌旁组织(6.69±0.10),差异有统计学意义(P＜0.01).TET1、TET2、TET3三者在胃癌组织中的表达无明显相关.TET1表达与幽门螺杆菌(Hp)感染、肿瘤大小、神经侵犯、淋巴转移、TNM分期显著相关(P＜0.05).生存分析显示TET1下调的患者总生存期显著减短,多因素分析显示TET1表达是胃癌预后独立的风险因素.结论 TET1下调与胃癌转移、临床分期显著相关,并提示预后不良.
目的 觀察胃癌組織和癌徬組織中的TET1、TET2、TET3蛋白錶達水平,探討三者相關性及臨床意義.方法 通過免疫組織化學方法檢測100例胃癌患者的腫瘸組織和癌徬組織中TET1、TET2、TET3蛋白錶達,分析其與臨床病理特徵和預後的相關性.結果 胃癌組織中TET1、TET2錶達水平為2.45±0.29、4.66±0.25,顯著低于癌徬組織(6.04±0.10、5.89 ±0.09),而TET3錶達水平(7.84±0.17)顯著高于癌徬組織(6.69±0.10),差異有統計學意義(P＜0.01).TET1、TET2、TET3三者在胃癌組織中的錶達無明顯相關.TET1錶達與幽門螺桿菌(Hp)感染、腫瘤大小、神經侵犯、淋巴轉移、TNM分期顯著相關(P＜0.05).生存分析顯示TET1下調的患者總生存期顯著減短,多因素分析顯示TET1錶達是胃癌預後獨立的風險因素.結論 TET1下調與胃癌轉移、臨床分期顯著相關,併提示預後不良.
목적 관찰위암조직화암방조직중적TET1、TET2、TET3단백표체수평,탐토삼자상관성급림상의의.방법 통과면역조직화학방법검측100례위암환자적종가조직화암방조직중TET1、TET2、TET3단백표체,분석기여림상병리특정화예후적상관성.결과 위암조직중TET1、TET2표체수평위2.45±0.29、4.66±0.25,현저저우암방조직(6.04±0.10、5.89 ±0.09),이TET3표체수평(7.84±0.17)현저고우암방조직(6.69±0.10),차이유통계학의의(P＜0.01).TET1、TET2、TET3삼자재위암조직중적표체무명현상관.TET1표체여유문라간균(Hp)감염、종류대소、신경침범、림파전이、TNM분기현저상관(P＜0.05).생존분석현시TET1하조적환자총생존기현저감단,다인소분석현시TET1표체시위암예후독립적풍험인소.결론 TET1하조여위암전이、림상분기현저상관,병제시예후불량.
Objective To measure the protein expression of ten-eleven translocation 1 (TET1),TET2,and TET3 genes in gastric cancer (GC) tissues and normal tissues,analyze the relationship between the expression level of TET genes and clinicopathological parameters,and determine the prognostic potential of TET protein in GC.Methods This study included 100 patients with GC.The expression levels of TET1,TET2,and TET3 proteins in tissues were detected by immunohistochemistry.The association of TET protein expression with clinicopathological characteristics was analyzed by the method of Person's chi-square test,and survival was calculated by log-rank test and Kaplan-Meier method.Cox regression model was used to perform multivariate analysis.Results The expression of TET1 (2.45 ± 0.29) and TET2 (4.66 ±0.25) in GC tissue was significantly lower than in normal tissue (6.04 ±0.10,and 5.89 ± 0.09),and TET3 expression level (7.84 ±0.17) in GC tissue was higher than in normal tissue (6.69 ± 0.10,P ＜ 0.01).The expression of TET1 in GC was related to Hp infection,tumor size,neural invasion,lymph node metastasis,and TNM stage significantly (P ＜ 0.05).In addition,the expression of TET3 in GC was correlated to neural invasion,vascular invasion,depth of invasion and TNM stage (P ＜ 0.05).Moreover,TET1 expression in GC tissue was associated with overall survival of patients with GC.Multivariate analysis showed that TET1 expression in GC was an independent impact factor for prognosis of GC patients [(hazard ratio (HR):0.036,95％ confidence interval (CI):0.002-0.681,P ＜ 0.05].Conclusion TET1 is down-regulated significantly in GC and TET1 expression correlates to metastasis and overall survival,suggesting that TET1 may be a potential marker for prognostic evaluation.
