CAJ | 학술논문

目的探讨内镜下切除(ER)与胃切除(GR)治疗早期胃癌的疗效差异.方法收于我院就诊并诊断为早期胃癌,分别接受内镜下切除和胃切除治疗的183例患者的临床资料.按治疗方案不同将患者分为内镜治疗组(ER)和胃切除组(GR),比较组间患者年龄分布、性别构成、既往史(基础疾病)、肿瘤位置(上端癌、中部癌、下端癌)、肿瘤大小(直径)、肿瘤分化程度及大体分型等基础状况的差异及术后并发症发生率、总体生存时间和无瘤生存时间的差异.结果按照接受治疗方案的不同,将183例患者分为GR组128例,ER组55例.患者年龄分布、性别构成及合并基础疾病等一般情况比较,组间差异无统计学意义(P＞0.05);患者疾病临床病理特征比较,患者肿瘸位置、分化程度及大体分型比较,组间差异无统计学意义(P＞0.05),然而与ER比较,GR组患者肿瘤相对较大[(1.62±0.55) cm比(1.31 ±0.42) cm],组间差异有统计学意义(P＜0.05);并发症发生率比较,组间差异无统计学意义(P＞0.05);患者总体生存时间与无瘤生存时间比较,组间差异无统计学意义(P＞0.05).结论对于符合内镜下切除治疗绝对适应证的早期胃癌患者,ER治疗效果与GR相当,可以考虑选择ER作为其常规治疗方案.
목적 탐토내경하절제(ER)여위절제(GR)치료조기위암적료효차이.방법 수우아원취진병진단위조기위암,분별접수내경하절제화위절제치료적183례환자적림상자료.안치료방안불동장환자분위내경치료조(ER)화위절제조(GR),비교조간환자년령분포、성별구성、기왕사(기출질병)、종류위치(상단암、중부암、하단암)、종류대소(직경)、종류분화정도급대체분형등기출상황적차이급술후병발증발생솔、총체생존시간화무류생존시간적차이.결과 안조접수치료방안적불동,장183례환자분위GR조128례,ER조55례.환자년령분포、성별구성급합병기출질병등일반정황비교,조간차이무통계학의의(P＞0.05);환자질병림상병리특정비교,환자종가위치、분화정도급대체분형비교,조간차이무통계학의의(P＞0.05),연이여ER비교,GR조환자종류상대교대[(1.62±0.55) cm비(1.31 ±0.42) cm],조간차이유통계학의의(P＜0.05);병발증발생솔비교,조간차이무통계학의의(P＞0.05);환자총체생존시간여무류생존시간비교,조간차이무통계학의의(P＞0.05).결론 대우부합내경하절제치료절대괄응증적조기위암환자,ER치료효과여GR상당,가이고필선택ER작위기상규치료방안.
Objective To investigate the the curative effectiveness of Endoscopic resection (ER) vs.Gastrectomy (GR) for early gastric cancer.Methods The clinical data of 183 patients who were diagnosed with early gastric cancer,and accepted ER or GR in our department were collected.Patients were divided into ER group and GR group.The differences in age distribution,gender composition,underlying disease,position,diameter and morphology of tumor were compared between two groups.The differences in the incidence rate of complications,overall survival rate and recurrence free survival rate were also compared between two groups.Results All the 183 patients were divided into GR group (n =128) and ER group (n =55).There was no significance difference in age distribution,gender composition,and underlying disease between two groups.There was no significant difference in position and morphology of tumors between two groups,but the tumor diameter in the GR group was bigger than in the ER group.There was no significance difference in the incidence rate of complications,overall survival rate and recurrence free survival rate between two groups.Conclusion For patients diagnosed with early gastric cancer meeting the absolute indications of ER,ER showed the same curative effectiveness as GR,and can be considered as a regular treatment for early gastric cancer.