中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
8期
1997-1999
,共3页
全身炎性反应综合征%ω-6多聚不饱和脂肪酸%ω-3多聚不饱和脂肪酸
全身炎性反應綜閤徵%ω-6多聚不飽和脂肪痠%ω-3多聚不飽和脂肪痠
전신염성반응종합정%ω-6다취불포화지방산%ω-3다취불포화지방산
Systemic inflammatory response syndrome%ω-6 polyunsaturated fatty acid%ω-3 polyunsaturated fatty acid
目的 比较使用ω-6多聚不饱和脂肪酸(对照组)和ω-3联合ω-6多聚不饱和脂肪酸(实验组)对全身炎性反应综合征患者肠外营养疗效.方法 将30例全身炎性反应综合征患者随机分为对照组(n=15)和实验组(n=15).观察并比较两组用药当天和用药后第6天血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1、IL-6、IL-8、急性生理与慢性健康状况评分Ⅱ(APACHEⅡ)评分、游走抑制因子(MIF)、谷草转氨酶、谷丙转氨酶和脂多糖等指标的差异.结果 使用后第6天,实验组和对照组的各项指标均较使用当天显著下降(P＜0.01),其中实验组中APACHEⅡ评分、TNF-α、IL-1和IL-6浓度较对照组中APACHEⅡ评分(16.2比14.4)、TNF-α(168.3 ng/L比108.2 ng/L)、IL-1(62.4 ng/L比53.6 ng/L)和IL-6((227.6 ng/L比187.5 ng/L)的下降幅度更高,差异有统计学意义(P＜0.05);两组中CRP(11.6 mg/L比9.4 mg/L)、MIF(13.5 μg/L比11.1 μg/L)、IL-8(11.8 ng/L比9.7 ng/L)、谷草转氨酶(38.1 μmol/L比43.8 μmol/L)、谷丙转氨酶(33.8 μmol/L比41.1 μmol/L)和脂多糖(74.0 μmol/L比80.9 μmol/L)浓度下降幅度差异无统计学意义(P＞0.05).结论 联合使用ω-3和ω-6多聚不饱和脂肪酸可较单独使用ω-6多聚不饱和脂肪酸更好地降低全身炎性反应综合征患者的炎症指标,有助于患者的恢复和预后的改善.
目的 比較使用ω-6多聚不飽和脂肪痠(對照組)和ω-3聯閤ω-6多聚不飽和脂肪痠(實驗組)對全身炎性反應綜閤徵患者腸外營養療效.方法 將30例全身炎性反應綜閤徵患者隨機分為對照組(n=15)和實驗組(n=15).觀察併比較兩組用藥噹天和用藥後第6天血清C反應蛋白(CRP)、腫瘤壞死因子-α(TNF-α)、白細胞介素(IL)-1、IL-6、IL-8、急性生理與慢性健康狀況評分Ⅱ(APACHEⅡ)評分、遊走抑製因子(MIF)、穀草轉氨酶、穀丙轉氨酶和脂多糖等指標的差異.結果 使用後第6天,實驗組和對照組的各項指標均較使用噹天顯著下降(P＜0.01),其中實驗組中APACHEⅡ評分、TNF-α、IL-1和IL-6濃度較對照組中APACHEⅡ評分(16.2比14.4)、TNF-α(168.3 ng/L比108.2 ng/L)、IL-1(62.4 ng/L比53.6 ng/L)和IL-6((227.6 ng/L比187.5 ng/L)的下降幅度更高,差異有統計學意義(P＜0.05);兩組中CRP(11.6 mg/L比9.4 mg/L)、MIF(13.5 μg/L比11.1 μg/L)、IL-8(11.8 ng/L比9.7 ng/L)、穀草轉氨酶(38.1 μmol/L比43.8 μmol/L)、穀丙轉氨酶(33.8 μmol/L比41.1 μmol/L)和脂多糖(74.0 μmol/L比80.9 μmol/L)濃度下降幅度差異無統計學意義(P＞0.05).結論 聯閤使用ω-3和ω-6多聚不飽和脂肪痠可較單獨使用ω-6多聚不飽和脂肪痠更好地降低全身炎性反應綜閤徵患者的炎癥指標,有助于患者的恢複和預後的改善.
목적 비교사용ω-6다취불포화지방산(대조조)화ω-3연합ω-6다취불포화지방산(실험조)대전신염성반응종합정환자장외영양료효.방법 장30례전신염성반응종합정환자수궤분위대조조(n=15)화실험조(n=15).관찰병비교량조용약당천화용약후제6천혈청C반응단백(CRP)、종류배사인자-α(TNF-α)、백세포개소(IL)-1、IL-6、IL-8、급성생리여만성건강상황평분Ⅱ(APACHEⅡ)평분、유주억제인자(MIF)、곡초전안매、곡병전안매화지다당등지표적차이.결과 사용후제6천,실험조화대조조적각항지표균교사용당천현저하강(P＜0.01),기중실험조중APACHEⅡ평분、TNF-α、IL-1화IL-6농도교대조조중APACHEⅡ평분(16.2비14.4)、TNF-α(168.3 ng/L비108.2 ng/L)、IL-1(62.4 ng/L비53.6 ng/L)화IL-6((227.6 ng/L비187.5 ng/L)적하강폭도경고,차이유통계학의의(P＜0.05);량조중CRP(11.6 mg/L비9.4 mg/L)、MIF(13.5 μg/L비11.1 μg/L)、IL-8(11.8 ng/L비9.7 ng/L)、곡초전안매(38.1 μmol/L비43.8 μmol/L)、곡병전안매(33.8 μmol/L비41.1 μmol/L)화지다당(74.0 μmol/L비80.9 μmol/L)농도하강폭도차이무통계학의의(P＞0.05).결론 연합사용ω-3화ω-6다취불포화지방산가교단독사용ω-6다취불포화지방산경호지강저전신염성반응종합정환자적염증지표,유조우환자적회복화예후적개선.
Objective To compare the external effectiveness of ω-6 polyunsaturated fatty acid (C-group) and ω-3 combined with ω-6 polyunsaturated fatty acid (T-group) for systemic inflammatory response syndrome (SIRS).Methods Thirty patients were randomly assigned into T-group (n =15) and C-group (n=15).The indexes of acute physiology and chronic health status score Ⅱ (APACHE Ⅱ) score,migratory inhibitory factor (MIF),aspertatestraw transaminase (AST),alanine aminotransferase (ALT) and lipopolysaccharide (LPS) on the same day (0 day) and 6 days after administration of drugs were recorded in detail.Results After 6 days of administration,concentrations of all indexes in T-group and C-group were significantly lower than on the 0 day after administration (P ＜ 0.01).The decreased magnitudes of TNF-α (168.3 ng/L vs.108.2 ng/L,P ＜ 0.01),IL-1 (62.4 ng/L vs.53.6 ng/L),IL-6 (227.6 ng/L vs.187.5 ng/L) and APACHE Ⅱ score (16.2 vs.14.4) in T-group were higher than in C-group(P ＜ 0.05).However,the difference in the decreased magnitude of C reactive protein (CRP,11.6 mg/L vs.9.4 mg/L),IL-8 (11.8 ng/L vs.9.7 ng/L),MIF (13.5 μg/L vs.11.1 μg/L),LPS (74.0 μmol/L vs.80.9 μmol/L),AST (38.1 μmol/L vs.43.8 μmol/L) and ALT (33.8 μmol/L vs.41.1 μmol/L) had no statistically significant difference between T-group and C-group (P ＞ 0.05).Conclusion Combined administration of ω-3 and ω-6 polyunsaturated fatty acid may play a better role in improving the effects of treatment,recovery and prognosis of patients than administration of ω-6 polyunsaturated fatty acid alone.
