CAJ | 학술논문

中枢神经系统中，脊髓中央管室管膜细胞(EC)具有一定的再生修复能力，是特化的不仅限于功能形态学的活性单位，后者作为特定的术语，它的意义超出生理学和解剖学定义。在损伤条件下，EC即可增殖分化为星形胶质细胞、少突胶质细胞和神经元。目前，复合生长因子和纤维蛋白支架的干细胞实验性治疗研究还存在长期疗效的争议。在中枢神经系统原位，使非神经元直接转化为功能性神经元研究方法，为脊髓损伤和疾病提供了新的治疗策略。在设计细胞治疗，如何控制EC增殖和分化或其他非神经元转化为神经元，继而形成和维持稳定有效的新生神经元功能，直至脊髓功能恢复仍然需要继续深入研究。我们需要一个全新的细胞组织概念，将神经干细胞栖地应用于中枢神经损伤等疾病的治疗和修复研究中，建立非传统的细胞分化和成熟的生物医疗微生态即环境再造治疗策略。
중추신경계통중，척수중앙관실관막세포(EC)구유일정적재생수복능력，시특화적불부한우공능형태학적활성단위，후자작위특정적술어，타적의의초출생이학화해부학정의。재손상조건하，EC즉가증식분화위성형효질세포、소돌효질세포화신경원。목전，복합생장인자화섬유단백지가적간세포실험성치료연구환존재장기료효적쟁의。재중추신경계통원위，사비신경원직접전화위공능성신경원연구방법，위척수손상화질병제공료신적치료책략。재설계세포치료，여하공제EC증식화분화혹기타비신경원전화위신경원，계이형성화유지은정유효적신생신경원공능，직지척수공능회복잉연수요계속심입연구。아문수요일개전신적세포조직개념，장신경간세포서지응용우중추신경손상등질병적치료화수복연구중，건립비전통적세포분화화성숙적생물의료미생태즉배경재조치료책략。
In the central nervous system, the ependymal cells (EC) in central canal of the spinal cord remain the persistence of a pool of stem and progenitor cells. Terminology of the EC niche as an entity of action not only showed neural stem cell potential but functioned beyond physiological and anatomical manners. The spinal cord EC generated astrocytes, oligodendrocytes and neurons in vitro and in vivo in injured spinal cord. However, it was still a challenge that the long term survival of spinal cord injury (SCI) treated by the stem cells transplanted in a fibrin matrix with a growth factor cocktail. Recently, the non-neuronal cells were directly converted into functional neurons in vivo, which opened up a new cellular therapy. With ultimate design of the therapeutics, we still need further to investigate how to manipulation of the proliferation and differentiation of EC or reprogramming of non-neuronal components into neuronal compartments,and constitute and functionally sustain the transplantation of stem cells and cellular modification in vivo until functional recovery in following SCI. We should figure out a new concept other than the traditional cell and tissue, stem cell niche, which could be non-traditionally mimicked in our human bodies to treatment of SCI under biomedical micro-ecology.