CAJ | 학술논문

目的：探讨3.0 T磁共振动态增强扫描(dynamic contrast-enhanced MRI，DCE-MRI)定量分析对前列腺癌和前列腺增生鉴别诊断的应用价值，并评价定量指标Ktrans、Kep、Ve与Gleason评分的相关性。材料与方法回顾性分析43例经病理证实的前列腺疾病患者的影像资料，其中前列腺癌(prostate cancer，PC)27例，前列腺增生(benign prostatic hyperplasia，BPH)16例，均行常规MRI和DCE-MRI检查，在定量分析软件上测量病灶的容积转运常数(Ktrans)、速率常数(Kep)、血管外细胞外容积分数(Ve)值，比较三者在前列腺癌组和增生组中的差异，并评价前列腺癌组Ktrans、Kep、Ve值与Gleason评分的相关性。结果前列腺癌组织的Ktrans、Kep、Ve分别为(0.312±0.085) min-1、(0.818±0.098) min-1和(0.379±0.031)，前列腺增生组织的Ktrans、Kep、Ve分别为(0.213±0.046) min-1、(0.537±0.076) min-1和(0.324±0.034)，前列腺癌组织的Ktrans、Kep、Ve明显高于增生组织，差异有统计学差异(P＜0.001)；前列腺癌区的Ktrans、Kep、Ve值与Gleason评分无明显相关性。结论 DCE-MRI定量分析在前列腺癌的诊断中具有较高价值，有利于前列腺良恶性病变的鉴别诊断。前列腺癌区的Ktrans、Kep、Ve值与Gleason评分无明显相关性。
목적：탐토3.0 T자공진동태증강소묘(dynamic contrast-enhanced MRI，DCE-MRI)정량분석대전렬선암화전렬선증생감별진단적응용개치，병평개정량지표Ktrans、Kep、Ve여Gleason평분적상관성。재료여방법회고성분석43례경병리증실적전렬선질병환자적영상자료，기중전렬선암(prostate cancer，PC)27례，전렬선증생(benign prostatic hyperplasia，BPH)16례，균행상규MRI화DCE-MRI검사，재정량분석연건상측량병조적용적전운상수(Ktrans)、속솔상수(Kep)、혈관외세포외용적분수(Ve)치，비교삼자재전렬선암조화증생조중적차이，병평개전렬선암조Ktrans、Kep、Ve치여Gleason평분적상관성。결과전렬선암조직적Ktrans、Kep、Ve분별위(0.312±0.085) min-1、(0.818±0.098) min-1화(0.379±0.031)，전렬선증생조직적Ktrans、Kep、Ve분별위(0.213±0.046) min-1、(0.537±0.076) min-1화(0.324±0.034)，전렬선암조직적Ktrans、Kep、Ve명현고우증생조직，차이유통계학차이(P＜0.001)；전렬선암구적Ktrans、Kep、Ve치여Gleason평분무명현상관성。결론 DCE-MRI정량분석재전렬선암적진단중구유교고개치，유리우전렬선량악성병변적감별진단。전렬선암구적Ktrans、Kep、Ve치여Gleason평분무명현상관성。
AbstractObjective:To explore the diagnostic value of quantitative analysis parameters of DCE-MRI in prostate cancer diagnosis, and to evaluate the correlation between Ktrans, Kep and Ve and Gleason scores. Materials and Methods:Forty-three prostate diseases patients pathologically proved underwent conventional MRI and DCE-MRI examinations, including 27 patients with prostate cancer and 16 with prostate hyperplasia. The variations of the value of Ktrans, Kep and Ve between the prostate cancer and hyperplastic tissues were measured and compared, and the correlations between Ktrans, Kep and Ve and Gleason scores were studied.Results:The Ktrans, Kep and Ve values of cancerous area were (0.312±0.085) min-1, (0.818±0.098) min-1 and (0.379±0.031), while, for hyperplastic area were (0.213±0.046) min-1, (0.537±0.076) min-1 and (0.324±0.034). The values of Ktrans, Kep, Ve were signiifcantly higher in prostate cancer than in hyperplastic tissues; and Ktrans, Kep, Ve values were not relevant with Gleason score.Conclusion:DCE-MRI quantitative analysis plays a signiifcant role in prostate cancer diagnosis, and may help in differential diagnosis of prostate tumors. Ktrans, Kep and Ve values were not relevant with Gleason score.