CAJ | 학술논문

目的：通过研究子宫肌瘤动态增强磁共振成像(dynamic contrast-enhanced MRI，DCE-MRI)定量参数与治疗效果的相关性，探讨定量参数对子宫肌瘤高强度聚焦超声(high intensity focused ultrasound，HIFU)治疗效果即时评估的应用价值。材料与方法回顾分析子宫肌瘤HIFU治疗的13个病例，根据治疗后DCE-MRI表现分为完全消融组及不完全消融组。应用Mann-Whitney U秩和检验和Spearman秩相关分析研究定量参数与分组的关联。结果 Ktrans(治疗后)、Ve(治疗后)、Vp(治疗后)与分组呈正相关，相关系数分别为r=0.713、0.757和0.668； Ktrans(变化率)、Ve(变化率)与分组呈负相关，相关系数均为r=-0.802，且相关性更显著。结论 DCE-MRI定量参数对子宫肌瘤HIFU治疗疗效即时评估具有参考价值。
목적：통과연구자궁기류동태증강자공진성상(dynamic contrast-enhanced MRI，DCE-MRI)정량삼수여치료효과적상관성，탐토정량삼수대자궁기류고강도취초초성(high intensity focused ultrasound，HIFU)치료효과즉시평고적응용개치。재료여방법회고분석자궁기류HIFU치료적13개병례，근거치료후DCE-MRI표현분위완전소융조급불완전소융조。응용Mann-Whitney U질화검험화Spearman질상관분석연구정량삼수여분조적관련。결과 Ktrans(치료후)、Ve(치료후)、Vp(치료후)여분조정정상관，상관계수분별위r=0.713、0.757화0.668； Ktrans(변화솔)、Ve(변화솔)여분조정부상관，상관계수균위r=-0.802，차상관성경현저。결론 DCE-MRI정량삼수대자궁기류HIFU치료료효즉시평고구유삼고개치。
AbstractObjective:To evaluate the immediate value of dynamic contrast-enhanced MRI(DCE-MRI)quantitative parameters after HIFU treatment of uterine fibroids. Materials and Methods:Thirteen patients with uterine fibroids were scanned with DCE-MRI before and after HIFU ablation. They were grouped into two groups, the complete ablation group and the non-complete ablation group according to appearance of DCE-MRI.Mann-Whitney U test andSpearman's correlations were applied to ifnd the association between quantitative parameters and grouping.Results:Ktrans(after treatment), Ve (after treatment) and Vp (after treatment) were positively correlated with the grouping, and correlation coefifcents were 0.713 , 0.757 and 0.668 respectively. Ktrans(rate of change)and Ve (rate of change) were negatively correlated with the grouping,and correlation coefifcients were both -0.802.Conclusion:DCE-MRI quantitative parameters have reference value in HIFU treatment's immediate effect evaluations for uterine ifbroids.