中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
13期
98-100
,共3页
克拉霉素%奥美拉唑%儿童慢性胃炎%幽门螺杆菌阳性
剋拉黴素%奧美拉唑%兒童慢性胃炎%幽門螺桿菌暘性
극랍매소%오미랍서%인동만성위염%유문라간균양성
Clarithromycin%Omeprazole%Children chronic gastritis%Positive helicobacter pylori
目的：探讨克拉霉素辅助治疗儿童幽门螺杆菌阳性慢性胃炎的临床疗效。方法选取2011年3月～2013年11月我院收治的58例幽门螺杆菌阳性的慢性胃炎患儿作为研究对象，采用随机数字表法将所选患儿分为研究组和对照组，各29例，研究组给予克拉霉素联合奥美拉唑治疗，对照组单独使用奥美拉唑治疗，随访1年，综合比较两组患儿治疗总有效率、幽门螺杆菌根除率、复发率和不良反应发生率。结果研究组治疗总有效率、幽门螺杆菌根除率分别为89.66%、93.10%，均高于对照组的65.52%、79.31%（P＜0.05）；随访1年，研究组复发率低于对照组（P＜0.05）；两组患儿不良反应发生率比较差异无统计学意义（P＞0.05）。结论克拉霉素联合奥美拉唑治疗幽门螺杆菌阳性的慢性胃炎患儿效果确切，可明显改善临床症状，降低复发率，患儿耐受性好，值得临床推广使用。
目的：探討剋拉黴素輔助治療兒童幽門螺桿菌暘性慢性胃炎的臨床療效。方法選取2011年3月～2013年11月我院收治的58例幽門螺桿菌暘性的慢性胃炎患兒作為研究對象，採用隨機數字錶法將所選患兒分為研究組和對照組，各29例，研究組給予剋拉黴素聯閤奧美拉唑治療，對照組單獨使用奧美拉唑治療，隨訪1年，綜閤比較兩組患兒治療總有效率、幽門螺桿菌根除率、複髮率和不良反應髮生率。結果研究組治療總有效率、幽門螺桿菌根除率分彆為89.66%、93.10%，均高于對照組的65.52%、79.31%（P＜0.05）；隨訪1年，研究組複髮率低于對照組（P＜0.05）；兩組患兒不良反應髮生率比較差異無統計學意義（P＞0.05）。結論剋拉黴素聯閤奧美拉唑治療幽門螺桿菌暘性的慢性胃炎患兒效果確切，可明顯改善臨床癥狀，降低複髮率，患兒耐受性好，值得臨床推廣使用。
목적：탐토극랍매소보조치료인동유문라간균양성만성위염적림상료효。방법선취2011년3월～2013년11월아원수치적58례유문라간균양성적만성위염환인작위연구대상，채용수궤수자표법장소선환인분위연구조화대조조，각29례，연구조급여극랍매소연합오미랍서치료，대조조단독사용오미랍서치료，수방1년，종합비교량조환인치료총유효솔、유문라간균근제솔、복발솔화불량반응발생솔。결과연구조치료총유효솔、유문라간균근제솔분별위89.66%、93.10%，균고우대조조적65.52%、79.31%（P＜0.05）；수방1년，연구조복발솔저우대조조（P＜0.05）；량조환인불량반응발생솔비교차이무통계학의의（P＞0.05）。결론극랍매소연합오미랍서치료유문라간균양성적만성위염환인효과학절，가명현개선림상증상，강저복발솔，환인내수성호，치득림상추엄사용。
Objective To explore the clinical efficacy of clarithromycin adjuvant therapy for the treatment of children's positive helicobacter pylori chronic gastritis.Methods58 children patients with positive helicobacter pylori chronic gastritis treated in our hospital during Mar, 2011 to Nov, 2013 were chosen as study objects and divided into research group and control group and 29 patients in each group. Patients in the research group were treated with clarithromycin combined with omeprazole, and patients in the control group were treated with omeprazole only. All the patients were followed up for one year. The total effective rate, Hp elimination rate, recurrence rate and the adverse effect rate of children patients in the two groups were comprehensively compared.ResultsThe total effective rate and Hp elimination rate of the research group were 89.66% and 93.10% respectively, higher than that of 65.52% and 79.31% in the control group (P<0.05). For one year follow-up, the recurrence rate of the research group was lower than that of the control group (P<0.05). The difference between the adverse effect rates of the two groups has no statistical significance (P>0.05). ConclusionThe combined use of clarithromycin and omeprazole in the treatment of children's positive helicobacter pylori chronic gastritis is effective and can remarkably improve clinical symptoms, reduce recurrence rate, to which children have good tolerance. The combined use mentioned above is worthy for clinical wide application.
