中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
13期
20-23
,共4页
急性冠脉综合征%血浆肌钙蛋白%血清脑钠肽%心肌酶谱
急性冠脈綜閤徵%血漿肌鈣蛋白%血清腦鈉肽%心肌酶譜
급성관맥종합정%혈장기개단백%혈청뇌납태%심기매보
Acute coronary syndrome%Cardiac troponin%Serum brain natriuretic peptide%Myocardial enzyme spectrum
目的:分析血浆心肌肌钙蛋白(cTnI)、血清脑钠肽(BNP)及心肌酶谱联合检测诊断急性冠脉综合征中的临床意义。方法选择确诊为急性冠脉综合征(ACS)患者35例作为观察组,和经冠状动脉造影检查显示正常的其他疾病患者35例作为对照组,应用即时检验(POCT)法检测cTnI、BNP、CK-MB、CK、AST、LDH浓度,比较分析两组差异以及和ACS之间的关系。结果观察组患者入院时cTnI、BNP、CK-MB、CK、AST、LDH浓度显著高于对照组患者(P<0.05);治疗10d后观察组患者cTnI、BNP浓度仍显著高于对照组患者(P<0.05),但CK-MB、CK、AST、LDH浓度和对照组相比无显著差异(P>0.05);治疗10d后,观察组患者cTnI、BNP浓度显著低于入院时的检测浓度(P<0.05)。结论使用POCT 法对cTnI、BNP及心肌酶谱进行联合检测并对治疗前后变化进行分析有助于早期明确诊断ACS并对治疗效果进行评估。
目的:分析血漿心肌肌鈣蛋白(cTnI)、血清腦鈉肽(BNP)及心肌酶譜聯閤檢測診斷急性冠脈綜閤徵中的臨床意義。方法選擇確診為急性冠脈綜閤徵(ACS)患者35例作為觀察組,和經冠狀動脈造影檢查顯示正常的其他疾病患者35例作為對照組,應用即時檢驗(POCT)法檢測cTnI、BNP、CK-MB、CK、AST、LDH濃度,比較分析兩組差異以及和ACS之間的關繫。結果觀察組患者入院時cTnI、BNP、CK-MB、CK、AST、LDH濃度顯著高于對照組患者(P<0.05);治療10d後觀察組患者cTnI、BNP濃度仍顯著高于對照組患者(P<0.05),但CK-MB、CK、AST、LDH濃度和對照組相比無顯著差異(P>0.05);治療10d後,觀察組患者cTnI、BNP濃度顯著低于入院時的檢測濃度(P<0.05)。結論使用POCT 法對cTnI、BNP及心肌酶譜進行聯閤檢測併對治療前後變化進行分析有助于早期明確診斷ACS併對治療效果進行評估。
목적:분석혈장심기기개단백(cTnI)、혈청뇌납태(BNP)급심기매보연합검측진단급성관맥종합정중적림상의의。방법선택학진위급성관맥종합정(ACS)환자35례작위관찰조,화경관상동맥조영검사현시정상적기타질병환자35례작위대조조,응용즉시검험(POCT)법검측cTnI、BNP、CK-MB、CK、AST、LDH농도,비교분석량조차이이급화ACS지간적관계。결과관찰조환자입원시cTnI、BNP、CK-MB、CK、AST、LDH농도현저고우대조조환자(P<0.05);치료10d후관찰조환자cTnI、BNP농도잉현저고우대조조환자(P<0.05),단CK-MB、CK、AST、LDH농도화대조조상비무현저차이(P>0.05);치료10d후,관찰조환자cTnI、BNP농도현저저우입원시적검측농도(P<0.05)。결론사용POCT 법대cTnI、BNP급심기매보진행연합검측병대치료전후변화진행분석유조우조기명학진단ACS병대치료효과진행평고。
Objective To analyze the clinical significance of combined detection of the plasma cardiac troponin (cTnI), serum brain natriuretic peptide (BNP) and myocardial enzyme spectrum in diagnosis of acute coronary syndrome.Methods 35 cases patients who diagnosed with acute coronary syndrome (ACS) were as the observation group, and 35 patients with other diseases whose coronary angiography revealed normal as control group. The levels of cTnI, BNP, CK-MB, CK, AST, LDH were detected by the real-time inspection (POCT) method,compared and analyzed the difference between two groups and the relationship with ACS.Results The levels of cTnI, BNP, CK-MB, CK, AST, LDH the patients in the observation group admission were significantly higher than those in the control group patients (P<0.05).The cTnI, BNP concentration of patients in the observation group after treatment for 10d were significantly higher than that of the control group patients (P<0.05),but the CK-MB, CK, AST, LDH concentration of two groups were no significant difference (P>0.05).After 10d treatment, cTnI and BNP concentration in observation group were significantly lower than that detection at admission (P<0.05).ConclusionThe combined detection of cTnI, BNP and myocardial enzyme spectrum by POCT method before and after the treatment are helpful to early diagnosis of ACS, and to assess the effectiveness of the treatment.