CAJ | 학술논문

目的：考察三黄细粉与三黄微粉的粉体学性质及体外溶出度，为其直接使用和作为中药制剂原料应用提供依据。方法对普通三黄细粉和三黄微粉的粒径分布、松密度与振实密度、休止角、吸湿性等粉体学性质进行考察和评价，采用紫外分光光度法测定二者体外溶出度并进行比较。结果三黄细粉及微粉的流动性均较差，随着粒径减小，微粉的吸湿性增强；三黄微粉较细粉的体外溶出更加迅速而充分。结论三黄微粉与三黄细粉的粉体学性质差异明显。三黄微粉的吸湿性更强，流动性欠佳，但溶出更迅速且充分，直接使用和作为中药制剂原料应用时需酌情处理。
목적：고찰삼황세분여삼황미분적분체학성질급체외용출도，위기직접사용화작위중약제제원료응용제공의거。방법대보통삼황세분화삼황미분적립경분포、송밀도여진실밀도、휴지각、흡습성등분체학성질진행고찰화평개，채용자외분광광도법측정이자체외용출도병진행비교。결과삼황세분급미분적류동성균교차，수착립경감소，미분적흡습성증강；삼황미분교세분적체외용출경가신속이충분。결론삼황미분여삼황세분적분체학성질차이명현。삼황미분적흡습성경강，류동성흠가，단용출경신속차충분，직접사용화작위중약제제원료응용시수작정처리。
Objective To compare the micromeritics properties and external dissolution rates of Sanhuang Powder in different particle sizes;To provide references for its direct use and application as raw materials for TCM preparation.Methods Particle size, bulk density, tap density, angle of repose, and hygroscopicity ofSanhuang micro-powder and common powder were investigated and evaluated. External dissolution rates ofSanhuang micro-powder and common powder were detected by ultraviolet spectrophotometry.Results The flowability of bothSanhuang micro-powder and common powder were not very well. With the sizes decreasing, the hygroscopicity of micro-powder became stronger. The external dissolution ofSanhuang micro-powder was more sufficient and much more quickly than common powder.Conclusion Properties ofSanhuang micro-powder and common powder are obviously different.Sanhuang micro-powder has stronger hygroscopicity and worse flowability compared with common powder. However, external dissolution ofSanhuang micro-powder is more sufficient and much more quickly than common powder. WhenSanhuang micro-powder is used directly and used as raw materials for TCM preparation, much more discretion should be considered.