中华现代护理杂志
中華現代護理雜誌
중화현대호리잡지
CHINESE JOURNAL OF MODERN NURSING
2015年
22期
2637-2639
,共3页
唐伟%周文艳%王晓辉%张亚仙%张镨月
唐偉%週文豔%王曉輝%張亞仙%張鐠月
당위%주문염%왕효휘%장아선%장보월
动物实验%兔%熊胆眼药水%中成药%刺激实验
動物實驗%兔%熊膽眼藥水%中成藥%刺激實驗
동물실험%토%웅담안약수%중성약%자격실험
Animal experiment%Rabbit%Bear bile eye drop%Chinese patent drug%Stimulating test
目的 探讨熊胆眼药水在频繁应用时对眼部的刺激反应,为药品使用的安全性提供实验依据. 方法 将熊胆眼药水以不同的频率(分别间隔1,5,10 min)滴入家兔右眼结膜囊,使用0. 9%氯化钠溶液滴入同一只家兔的左眼作为对照,每次均滴入1滴,连续滴入10次. 于最后1次滴药后0,6,24, 48 h,观察家兔的眼部刺激反应. 结果 间隔5,10 min组,家兔右眼眼结膜无充血、水肿、分泌物,虹膜正常,也无角膜混浊,根据眼刺激反应评分标准,其评分为1分,属无刺激. 间隔1 min组家兔右眼在实验完毕后观察,显示结膜轻度充血,轻度水肿,结膜囊分泌物增多,评分平均为5分,属轻度刺激;在6h观察时评分下降为平均3分,属无刺激性;12 h后评分平均值下降为1分以下. 结论 熊胆眼药水在高频率使用时可对兔眼造成轻度刺激,其刺激反应可逆,总体安全性较高,但应避免高频率使用.
目的 探討熊膽眼藥水在頻繁應用時對眼部的刺激反應,為藥品使用的安全性提供實驗依據. 方法 將熊膽眼藥水以不同的頻率(分彆間隔1,5,10 min)滴入傢兔右眼結膜囊,使用0. 9%氯化鈉溶液滴入同一隻傢兔的左眼作為對照,每次均滴入1滴,連續滴入10次. 于最後1次滴藥後0,6,24, 48 h,觀察傢兔的眼部刺激反應. 結果 間隔5,10 min組,傢兔右眼眼結膜無充血、水腫、分泌物,虹膜正常,也無角膜混濁,根據眼刺激反應評分標準,其評分為1分,屬無刺激. 間隔1 min組傢兔右眼在實驗完畢後觀察,顯示結膜輕度充血,輕度水腫,結膜囊分泌物增多,評分平均為5分,屬輕度刺激;在6h觀察時評分下降為平均3分,屬無刺激性;12 h後評分平均值下降為1分以下. 結論 熊膽眼藥水在高頻率使用時可對兔眼造成輕度刺激,其刺激反應可逆,總體安全性較高,但應避免高頻率使用.
목적 탐토웅담안약수재빈번응용시대안부적자격반응,위약품사용적안전성제공실험의거. 방법 장웅담안약수이불동적빈솔(분별간격1,5,10 min)적입가토우안결막낭,사용0. 9%록화납용액적입동일지가토적좌안작위대조,매차균적입1적,련속적입10차. 우최후1차적약후0,6,24, 48 h,관찰가토적안부자격반응. 결과 간격5,10 min조,가토우안안결막무충혈、수종、분비물,홍막정상,야무각막혼탁,근거안자격반응평분표준,기평분위1분,속무자격. 간격1 min조가토우안재실험완필후관찰,현시결막경도충혈,경도수종,결막낭분비물증다,평분평균위5분,속경도자격;재6h관찰시평분하강위평균3분,속무자격성;12 h후평분평균치하강위1분이하. 결론 웅담안약수재고빈솔사용시가대토안조성경도자격,기자격반응가역,총체안전성교고,단응피면고빈솔사용.
Objective To explore the stimulating effect of bear bile eye drops on rabbit eyes frequently in order to provide experimental basis for drug use. Methods Bear bile eye drops dripped into the right eye of rabbit conjunctival sac as experimental group ( different frequency as 1, 5, 10 min) while normal saline was used in the left eye of rabbit as the control group ( one drop once and 10 times continually) . We observed the stimulation of rabbit eyes at 0, 6, 12, 24, 48 hours after the last dripping. Results At the observation of 5 and 10 min interval set, the right eyes of rabbit had no hyperemia, no edema, no secretion, no maculae corneae, and normal iris that was 1 score according to eye stimulation response scale belonging no irritation. After 1 min interval set observation of right eyes, they presented light conjunctiva hyperemia, light edema, increased secretion of conjunctiva sac with 5 score belonging to light stimulation;but it decreased to 3 scores at 6 h interval set belonging to no stimulation;the average score declined underneath 1 score at the observation of 12 h interval set. Conclusions Bear bile eye drops can arouse reversible light stimulation when used in high frequency, so the safety is high, but we should avoid the high frequency of use.
