中国中医药信息杂志
中國中醫藥信息雜誌
중국중의약신식잡지
CHINESE JOURNAL OF INFORMATION ON TRADITIONAL CHINESE MEDICINE
2015年
9期
33-36
,共4页
难治性丙型肝炎%益气解毒化瘀汤%临床疗效
難治性丙型肝炎%益氣解毒化瘀湯%臨床療效
난치성병형간염%익기해독화어탕%림상료효
refractory hepatitis C%Yiqi Jiedu Huayu Decoction%clinical efficacy
目的：观察自拟益气解毒化瘀汤治疗难治性丙型肝炎的临床疗效。方法将60例患者用随机数字表法分为中药组和西药组，每组30例。中药组予自拟益气解毒化瘀汤治疗，西药组予聚乙二醇干扰素联合利巴韦林治疗。2组疗程均为12个月。观察2组治疗前后中医证候积分、丙氨酸氨基转移酶(ALT)和天冬氨酸氨基转移酶(AST)水平、丙型肝炎病毒(HCV)RNA载量，对临床疗效进行对比分析。结果中药组总有效率为80.00%(24/30)，与西药组比较，差异有统计学意义(P＜0.05)；中药组中医证候积分、ALT水平及HCV RNA载量改善优于西药组，差异有统计学意义(P＜0.05)。结论益气解毒化瘀汤能明显改善患者的临床症状和体征，且有一定的抗病毒作用，有助于提高临床疗效。
目的：觀察自擬益氣解毒化瘀湯治療難治性丙型肝炎的臨床療效。方法將60例患者用隨機數字錶法分為中藥組和西藥組，每組30例。中藥組予自擬益氣解毒化瘀湯治療，西藥組予聚乙二醇榦擾素聯閤利巴韋林治療。2組療程均為12箇月。觀察2組治療前後中醫證候積分、丙氨痠氨基轉移酶(ALT)和天鼕氨痠氨基轉移酶(AST)水平、丙型肝炎病毒(HCV)RNA載量，對臨床療效進行對比分析。結果中藥組總有效率為80.00%(24/30)，與西藥組比較，差異有統計學意義(P＜0.05)；中藥組中醫證候積分、ALT水平及HCV RNA載量改善優于西藥組，差異有統計學意義(P＜0.05)。結論益氣解毒化瘀湯能明顯改善患者的臨床癥狀和體徵，且有一定的抗病毒作用，有助于提高臨床療效。
목적：관찰자의익기해독화어탕치료난치성병형간염적림상료효。방법장60례환자용수궤수자표법분위중약조화서약조，매조30례。중약조여자의익기해독화어탕치료，서약조여취을이순간우소연합리파위림치료。2조료정균위12개월。관찰2조치료전후중의증후적분、병안산안기전이매(ALT)화천동안산안기전이매(AST)수평、병형간염병독(HCV)RNA재량，대림상료효진행대비분석。결과중약조총유효솔위80.00%(24/30)，여서약조비교，차이유통계학의의(P＜0.05)；중약조중의증후적분、ALT수평급HCV RNA재량개선우우서약조，차이유통계학의의(P＜0.05)。결론익기해독화어탕능명현개선환자적림상증상화체정，차유일정적항병독작용，유조우제고림상료효。
Objective To observe the clinical efficacy of self-madeYiqi Jiedu Huayu Decoction for treatment of refractory hepatitis C.Methods Sixty cases were randomly divided into Chinese herbal medicine (CHM) group and Western medicine (WM) group, 30 cases in each group. The CHM group was treated by self-madeYiqi Jiedu HuayuDecoction, while the WM group was treated by peginterferon and ribavirin. The course for the two groups lasted for 12 months. TCM syndrome scores, level of ALT and AST, HCV RNA load were observed, and clinical efficacy were analyzed comparatively.Results The total effect rate of CHM group was 80.00% (24/30), with statistical difference compared with the WM group (P<0.05). TCM syndrome scores, level of ALT and HCV RNA load of CHM group were improved better than those of the WM group, with statistical differences (P<0.05).Conclusion Self-madeYiqi Jiedu Huayu Decoction can obviously improve clinical symptoms and signs, and has positive antiviral effect, which can help to improve the clinical efficacy.
