CAJ | 학술논문

目的：观察化瘀抗幽方联合西药治疗幽门螺杆菌(Hp)相关性溃疡临床疗效，并探讨其作用机理。方法将152例患者随机分为治疗组和对照组各76例，对照组予标准三联疗法，治疗组在标准三联疗法基础上予自拟方化瘀抗幽汤治疗，疗程6周，观察2组患者治疗前后临床症状积分、胃镜，记录不良反应，评价临床疗效，随访溃疡复发情况。结果治疗组、对照组临床总有效率分别为94.74%(72/76)、84.21%(64/76)，治疗优良率分别为78.95%(60/76)、55.26%(42/76)，不良反应发生率分别为5.26%(4/76)、13.16%(10/76)，随访1年复发率分别为13.63%(6/44)、41.67%(10/24)，差异均有统计学意义(P＜0.05)。结论化瘀抗幽方联合西药治疗Hp相关性溃疡能够提高临床疗效，减少不良反应，降低溃疡复发率。
목적：관찰화어항유방연합서약치료유문라간균(Hp)상관성궤양림상료효，병탐토기작용궤리。방법장152례환자수궤분위치료조화대조조각76례，대조조여표준삼련요법，치료조재표준삼련요법기출상여자의방화어항유탕치료，료정6주，관찰2조환자치료전후림상증상적분、위경，기록불량반응，평개림상료효，수방궤양복발정황。결과치료조、대조조림상총유효솔분별위94.74%(72/76)、84.21%(64/76)，치료우량솔분별위78.95%(60/76)、55.26%(42/76)，불량반응발생솔분별위5.26%(4/76)、13.16%(10/76)，수방1년복발솔분별위13.63%(6/44)、41.67%(10/24)，차이균유통계학의의(P＜0.05)。결론화어항유방연합서약치료Hp상관성궤양능구제고림상료효，감소불량반응，강저궤양복발솔。
Objective To observe the efficacy ofHuayu Kangyou Formula combined with Western medicine for Hp-related peptic ulcer disease;To discuss the mechanism of action.Methods Totally 152 patients were randomly divided into treatment group and control group, 76 cases in each group. Control group was given standard triple therapy, while treatment group was givenHuayu Kangyou Formula based on the standard triple therapy. The treatment lasted for 6 weeks. The clincal symptom scores and gastroscopy were observed to evaluate the therapeutic effect, adverse reactions were recorded, and relapse of ulcer was followed-up.Results The total effective rates of clinical symptoms in the treatment group and the control group were 94.74% (72/76) and 84.21% (64/76), respectively;the excellent rates were 78.95% (60/76) and 55.26% (42/76), respectively;the incidences of adverse reactions were 5.26% (4/76) and 13.16% (10/76), respectively;the relapse rates after 1 year of follow-up visit were 13.63% (6/44) and 41.67% (10/24), respectively, with statistical significant difference between the two groups (P<0.05).ConclusionHuayu Kangyou Formula combined with Western medicine can effectively improve the efficacy of Hp-relative peptic ulcer disease, reduce adverse reaction rate and relapse rate.