CAJ | 학술논문

目的：评价自拟方红藤肠安汤治疗轻中度溃疡性结肠炎(UC)的临床疗效及安全性。方法选择120例轻中度 UC 患者，随机分为中药组和西药组各60例，中药组予自拟方红藤肠安汤，西药组予美沙拉嗪肠溶片，疗程均为6周，随访2周。观察并比较2组患者治疗前后红细胞沉降率(ESR)和血清C反应蛋白(CRP)水平变化、肠镜下结肠黏膜愈合情况(根据Baron评分)、临床疗效及安全性。结果2组患者治疗后CRP水平均较治疗前降低，差异有统计学意义(P＜0.05)；2组患者治疗后 ESR 降低，但差异无统计学意义(P＞0.05)。肠镜下结肠黏膜愈合有效率中药组为61.37%(27/44)，西药组为64.29%(27/42)，组间比较差异无统计学意义(P＞0.05)。临床总有效率中药组为86.7%(52/60)，西药组为75.0%(45/60)，中药组优于西药组(P＜0.05)。中药组未出现不良反应。结论红藤肠安汤能有效降低轻中度UC患者血清CRP水平，缓解炎症，促进结肠黏膜愈合，具有良好的临床疗效，且无不良反应。
목적：평개자의방홍등장안탕치료경중도궤양성결장염(UC)적림상료효급안전성。방법선택120례경중도 UC 환자，수궤분위중약조화서약조각60례，중약조여자의방홍등장안탕，서약조여미사랍진장용편，료정균위6주，수방2주。관찰병비교2조환자치료전후홍세포침강솔(ESR)화혈청C반응단백(CRP)수평변화、장경하결장점막유합정황(근거Baron평분)、림상료효급안전성。결과2조환자치료후CRP수평균교치료전강저，차이유통계학의의(P＜0.05)；2조환자치료후 ESR 강저，단차이무통계학의의(P＞0.05)。장경하결장점막유합유효솔중약조위61.37%(27/44)，서약조위64.29%(27/42)，조간비교차이무통계학의의(P＞0.05)。림상총유효솔중약조위86.7%(52/60)，서약조위75.0%(45/60)，중약조우우서약조(P＜0.05)。중약조미출현불량반응。결론홍등장안탕능유효강저경중도UC환자혈청CRP수평，완해염증，촉진결장점막유합，구유량호적림상료효，차무불량반응。
Objective To evaluate the clinical efficacy and safety ofHongteng Chang'an Decoction in treating mild and moderate ulcerative colitis (UC) cases.Methods Totally 120 patients of mild or moderate UC were randomly divided into two groups:TCM group of 60 patients, treated by self-madeHongteng Chang'an Decoction;Western medicine group of 60 patients, treated by mesalazine orally. The treatment course of both groups was 6 weeks, also with two-week follow-up. The ESR and CRP levels before and after treatment, the healing of colonic mucosa under endoscopy (according to the Baron score), the clinical efficacy and safety were analyzed statistically.Results CRP of both groups decreased significantly, with obvious statistical significance (P<0.05);ESR of both groups decreased, without statistical significance (P>0.05). The effects of healing of colonic mucosa under endoscopy of TCM group and Western medicine group were 61.37% (27/44) and 64.29% (27/42), respectively, without obvious statistical significance (P>0.05). The total effective rates of TCM group and Western medicine group were 86.7% (52/60) and 75.0% (45/60), respectively, and the TCM group was superior to the Western medicine group (P<0.05).ConclusionHongteng Chang'an Decoction can reduce the serum level of CRP of the mild and moderate UC patients effectively, relieve inflammation, and promote the healing of colonic mucosa. The treatment of mild and moderate ulcerative colitis byHongteng Chang'an Decoction has good clinical efficacy, without toxic side effects.