CAJ | 학술논문

疼痛与抑郁共病在一些内科疾病患者身上很常见。经研究发现炎症是抑郁与疼痛共病的可能机制。这些机制包括细胞因子对神经元环境发挥直接作用与下调G蛋白耦联受体激酶2，激活色氨酸代谢酶（吲哚2，3-双加氧酶）产生有毒的犬尿素代谢产物而发挥间接作用。文中就疼痛与抑郁共病的炎症机制作一综述。
동통여억욱공병재일사내과질병환자신상흔상견。경연구발현염증시억욱여동통공병적가능궤제。저사궤제포괄세포인자대신경원배경발휘직접작용여하조G단백우련수체격매2，격활색안산대사매（신타2，3-쌍가양매）산생유독적견뇨소대사산물이발휘간접작용。문중취동통여억욱공병적염증궤제작일종술。
Comorbid depression and chronic pain are highly prevalent in individuals suffering from physical illness .Here, we critically examine that inflammation is the possible mechanism of comorbidity of pain and depression .These mechanisms include direct effects of cytokines on the neuronal environment or indirect effects via downregulation of G protein -coupled receptor kinase 2, activation of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase that generates toxic kynurenine metabolites .We review the role of in-flammation in the mechanism of the commorbidity of depression and pain .