CAJ | 학술논문

关节软骨细胞长期暴露于不同程度的低氧环境中，低氧诱导因子（ hypoxia inducible factors ， HIFs）是关节软骨适应低氧环境的一个关键性调控因子，它对关节软骨细胞的代谢、修复及退化等均有重要作用。文中就HIFs对软骨细胞的综合作用作一综述。
관절연골세포장기폭로우불동정도적저양배경중，저양유도인자（ hypoxia inducible factors ， HIFs）시관절연골괄응저양배경적일개관건성조공인자，타대관절연골세포적대사、수복급퇴화등균유중요작용。문중취HIFs대연골세포적종합작용작일종술。
Because articular chondrocytes have a long-term exposure to different degrees of hypoxic environment , hypoxia induc-ible factor is considered to be one of the most important regulation factors to adapt to low oxygen levels .It plays a significant role in the metabolism, repair, and degeneration of cartilage chondrocyts .This article reviews the comprehensive effects of hypoxia inducible fac-tor in cartilage chondrocyts .