CAJ | 학술논문

肺纤维化是全球肺部疾病发病率和死亡率的重要原因之一，目前尚无有效的防治措施。近年研究显示，高迁移率族蛋白B1（high mobility group protein B1， HMGB1）在肺纤维化的发生发展中具有重要作用，若干HMGB1拮抗剂可以减轻动物肺纤维化。文中就HMGB1的结构、功能和胞内信号转导、HMGB1在肺纤维化中的表达改变及其作用以及肺纤维化的HMGB1靶向治疗等具体内容和具体作用进行综述，以期对肺纤维化的临床治疗提供借鉴。
폐섬유화시전구폐부질병발병솔화사망솔적중요원인지일，목전상무유효적방치조시。근년연구현시，고천이솔족단백B1（high mobility group protein B1， HMGB1）재폐섬유화적발생발전중구유중요작용，약간HMGB1길항제가이감경동물폐섬유화。문중취HMGB1적결구、공능화포내신호전도、HMGB1재폐섬유화중적표체개변급기작용이급폐섬유화적HMGB1파향치료등구체내용화구체작용진행종술，이기대폐섬유화적림상치료제공차감。
Pulmonary fibrosis , an important cause of pulmonary diseases , has no effective protective and therapeutic meas-ures.Recent studies showed high mobility group protein B 1 (HMGB1) has an important role in the development of pulmonary fibrosis and many HMGB1 antagonists can alleviate pulmonary fibrosis in animal models .This paper summarizes the structure , function, intra-cellular signal transduction of HMGB1, the expression change of HMGB1 in pulmonary fibrosis and HMGB1 targeted therapy in pulmo-nary fibrosis in order to provide an effective basis for clinical treatment of pulmonary fibrosis .