CAJ | 학술논문

目的：临床观察显示，抗真菌治疗可显著改善合并皮肤癣菌感染的变态反应性皮肤疾病的患者症状。文中观察特比萘芬片联合咪唑斯汀治疗伴有皮肤癣菌感染慢性湿疹患者的疗效，明确皮肤癣菌感染在此类湿疹病因学中的作用。方法收集南京军区南京总医院皮肤科门诊2011年10月至2012年10月临床确诊为慢性湿疹的患者84例。按随机数字表法将受试者分为2组，对湿疹面积和严重度指数（Eczema Area and Severity Index ， EASI）评分者施盲。治疗组口服特比萘芬片及咪唑斯汀，对照组仅给咪唑斯汀服用，分别比较2组在治疗第2、3周的EASI评分、痊愈率、有效率，以及停药4周后2组EASI评分及复发率情况。结果试验过程中5例患者退出，最终共有79例患者最终完成试验。治疗第2、3周，2组患者EASI、有效率差异均有统计学意义（ P＜0．05）；停药4周后，治疗组EASI值及复发率均明显低于对照组，差异有统计学意义（P＜0．05）。结论口服特比奈芬联合咪唑斯汀治疗伴有皮肤癣菌感染的慢性湿疹，有效率及复发率均明显高于仅口服咪唑斯汀患者，提示皮肤癣菌感染在慢性湿疹的病因学中具有一定的病因学作用。
목적：림상관찰현시，항진균치료가현저개선합병피부선균감염적변태반응성피부질병적환자증상。문중관찰특비내분편연합미서사정치료반유피부선균감염만성습진환자적료효，명학피부선균감염재차류습진병인학중적작용。방법수집남경군구남경총의원피부과문진2011년10월지2012년10월림상학진위만성습진적환자84례。안수궤수자표법장수시자분위2조，대습진면적화엄중도지수（Eczema Area and Severity Index ， EASI）평분자시맹。치료조구복특비내분편급미서사정，대조조부급미서사정복용，분별비교2조재치료제2、3주적EASI평분、전유솔、유효솔，이급정약4주후2조EASI평분급복발솔정황。결과시험과정중5례환자퇴출，최종공유79례환자최종완성시험。치료제2、3주，2조환자EASI、유효솔차이균유통계학의의（ P＜0．05）；정약4주후，치료조EASI치급복발솔균명현저우대조조，차이유통계학의의（P＜0．05）。결론구복특비내분연합미서사정치료반유피부선균감염적만성습진，유효솔급복발솔균명현고우부구복미서사정환자，제시피부선균감염재만성습진적병인학중구유일정적병인학작용。
Objective The article was to observe the clinical efficacy of the application of terbinafine and mizolastine in com -bined treatment of chronic eczema ( CE) with dermatophytes infection , so as to define the etiology role of dermatophytes in allergic dis-eases. Methods All subjects were randomly divided into experiment group and control group .The experiment group was treated with the combination of terbinafine and mizolastine , while the control group took mizolastine orally alone .EASI grading , recovery rate and effective rate were evaluated at 2, 3 week after the treatment and EASI grading and recurrence rate were evaluated at 4 weeks after the treatment. Results 79 patients had finished the experiment .Significant difference was found in the effective rates between two groups at 3 weeks after treatment (P<0.05).At 4 weeks after the treatment, EASI value and recurrence rate in experiment group were obviously lower than those in control group (P<0.05). Conclusion Good therapeutic effect has been achieved through the ap-plication of terbinafine and mizolastine in combined treatment of CE with dermatophytes infection , which implies dermatophytes plays an important role in the etiology of CE .