CAJ | 학술논문

目的：探讨脂蛋白脂酶（L PL ）基因rs328多态性与汉族人脑梗死的相关性。方法选择150例汉族脑梗死患者，按类肝素药物治疗急性缺血性脑卒中试验（TOAST ）分型标准，分为大动脉粥样硬化（LAA）亚组和小动脉闭塞（SAO）亚组，并选择160名健康体检人群为对照组。以rs328位点为遗传标记，应用聚合酶链反应分析L PL基因rs328多态性与脑梗死的相关性。结果①脑梗死组基因型频率与对照组相比，差异无统计学意义（P＞0.05）。LAA亚组基因型频率与对照组相比，差异有统计学意义（P＜0.05）。②LAA亚组rs328位点G等位基因频率为12.50％，与对照组的6.56％比较，LAA亚组明显增高[P＜0.05，OR＝2.034，95％ CI（1.183，2.485）]。SAO亚组rs328位点等位基因频率与对照组差异无统计学意义（P＞0.05）。结论 LPL rs328位点基因多态性与汉族人脑梗死的发病相关，G等位基因携带者患大动脉粥样硬化性脑梗死的风险高于非携带者。
목적：탐토지단백지매（L PL ）기인rs328다태성여한족인뇌경사적상관성。방법선택150례한족뇌경사환자，안류간소약물치료급성결혈성뇌졸중시험（TOAST ）분형표준，분위대동맥죽양경화（LAA）아조화소동맥폐새（SAO）아조，병선택160명건강체검인군위대조조。이rs328위점위유전표기，응용취합매련반응분석L PL기인rs328다태성여뇌경사적상관성。결과①뇌경사조기인형빈솔여대조조상비，차이무통계학의의（P＞0.05）。LAA아조기인형빈솔여대조조상비，차이유통계학의의（P＜0.05）。②LAA아조rs328위점G등위기인빈솔위12.50％，여대조조적6.56％비교，LAA아조명현증고[P＜0.05，OR＝2.034，95％ CI（1.183，2.485）]。SAO아조rs328위점등위기인빈솔여대조조차이무통계학의의（P＞0.05）。결론 LPL rs328위점기인다태성여한족인뇌경사적발병상관，G등위기인휴대자환대동맥죽양경화성뇌경사적풍험고우비휴대자。
Objective To study the correlation between rs328 polymorphism of lipoprotein lipase (LPL ) gene and Chinese Han cerebral infarction .Methods One hundred and fifty Han patients with cerebral infarction were selected as the infarction group ,and were divided into large‐artery atherosclerosis (LAA ) subgroup and small‐artery occlusion (SAO ) subgroup according to TOAST classification standard . One hundred and sixty healthy people were selected as the control group .The relationship between rs328 polymorphism of LPL gene and cerebral infarction were analyzed by polymerase chain reaction ,with rs328 site as a genetic marker .Results ①There was no statistically significant difference of genotypic frequency between cerebral infarction group and con‐trol group (P> 0.05) .There was statistically significant difference of genotypic frequency between LAA sub‐group and control group (P<0.05) .② In rs328 site ,the allele frequency was 12.50% in LAA group ,higher than 6.56% in control group[P<0.05 ,OR=2.034 ,95% CI (1.183 ,2.485)] .There was no statistical difference of allele frequency between SAO subgroup and control group in rs328 site(P>0 .05) .Conclusion The rs328 poly‐morphism of LPL gene is related with Chinese Han cerebral infarction .Carriers of G allele have the higher risks of LAA cerebral infarction than non carriers .