中华肝脏外科手术学电子杂志
中華肝髒外科手術學電子雜誌
중화간장외과수술학전자잡지
CHINESE JOURNAL OF HEPATIC SURGERY(ELECTRONIC EDITION)
2015年
4期
250-253
,共4页
杨跃武%叶志强%孔庆磊%罗刚健
楊躍武%葉誌彊%孔慶磊%囉剛健
양약무%협지강%공경뢰%라강건
癌,肝细胞%c-Jun%预后
癌,肝細胞%c-Jun%預後
암,간세포%c-Jun%예후
Carcinoma,hepatocellular%c-Jun%Prognosis
目的：探讨c-Jun蛋白在肝细胞癌（肝癌）中的表达及其与预后的关系。方法回顾性分析2010年1月至2013年12月在中山大学附属第三医院行肝切除术的137例肝癌患者临床资料。其中男112例，女25例；年龄26～73岁，中位年龄45岁。所有患者均签署知情同意书，符合医学伦理学规定。采用免疫组化法检测肝癌组织c-Jun蛋白表达。根据免疫组化法染色评分将患者分为高表达组（75例）和低表达组（62例）。分析两组患者临床病理学参数及c-Jun蛋白表达与生存预后的关系。两组患者临床病理学参数比较采用χ2检验，生存分析采用Kaplan-Meier法和Log-rank检验。结果肝癌c-Jun蛋白表达与患者HBsAg、AFP、肿瘤直径、肿瘤包膜、肿瘤血管侵犯有关（χ2=5.27，32.68，4.86，1.04，4.62；P<0.05）。高表达组患者3、5年累积生存率分别为64.14%、41.20%，低表达组相应为72.04%、61.21%，高表达组患者的总体生存率明显低于低表达组（χ2=5.19，P<0.05）。结论 c-Jun蛋白可能在肝癌的发生、发展中起到重要作用，其高表达预示患者预后不良。
目的：探討c-Jun蛋白在肝細胞癌（肝癌）中的錶達及其與預後的關繫。方法迴顧性分析2010年1月至2013年12月在中山大學附屬第三醫院行肝切除術的137例肝癌患者臨床資料。其中男112例，女25例；年齡26～73歲，中位年齡45歲。所有患者均籤署知情同意書，符閤醫學倫理學規定。採用免疫組化法檢測肝癌組織c-Jun蛋白錶達。根據免疫組化法染色評分將患者分為高錶達組（75例）和低錶達組（62例）。分析兩組患者臨床病理學參數及c-Jun蛋白錶達與生存預後的關繫。兩組患者臨床病理學參數比較採用χ2檢驗，生存分析採用Kaplan-Meier法和Log-rank檢驗。結果肝癌c-Jun蛋白錶達與患者HBsAg、AFP、腫瘤直徑、腫瘤包膜、腫瘤血管侵犯有關（χ2=5.27，32.68，4.86，1.04，4.62；P<0.05）。高錶達組患者3、5年纍積生存率分彆為64.14%、41.20%，低錶達組相應為72.04%、61.21%，高錶達組患者的總體生存率明顯低于低錶達組（χ2=5.19，P<0.05）。結論 c-Jun蛋白可能在肝癌的髮生、髮展中起到重要作用，其高錶達預示患者預後不良。
목적：탐토c-Jun단백재간세포암（간암）중적표체급기여예후적관계。방법회고성분석2010년1월지2013년12월재중산대학부속제삼의원행간절제술적137례간암환자림상자료。기중남112례，녀25례；년령26～73세，중위년령45세。소유환자균첨서지정동의서，부합의학윤리학규정。채용면역조화법검측간암조직c-Jun단백표체。근거면역조화법염색평분장환자분위고표체조（75례）화저표체조（62례）。분석량조환자림상병이학삼수급c-Jun단백표체여생존예후적관계。량조환자림상병이학삼수비교채용χ2검험，생존분석채용Kaplan-Meier법화Log-rank검험。결과간암c-Jun단백표체여환자HBsAg、AFP、종류직경、종류포막、종류혈관침범유관（χ2=5.27，32.68，4.86，1.04，4.62；P<0.05）。고표체조환자3、5년루적생존솔분별위64.14%、41.20%，저표체조상응위72.04%、61.21%，고표체조환자적총체생존솔명현저우저표체조（χ2=5.19，P<0.05）。결론 c-Jun단백가능재간암적발생、발전중기도중요작용，기고표체예시환자예후불량。
ObjectiveTo investigate the expression of c-Jun in hepatocellular carcinoma (HCC) and its correlation with prognosis.MethodsClinical data of 137 patients with HCC undergoing hepatectomy in the Third Affiliated Hospital of Sun Yat-sen University between Janunary 2010 and December 2013 were retrospectively studied. Among the 137 patients, 112 were males and 25 were females with the age ranging from 26 to 73 years old and the median of 45 years old. The informed consents of all patients were obtained and the local ethical committee approval had been received. The expression of c-Jun in HCC tissues was detected by immunohistochemistry. The patients were divided into the high-expression group (n=75) and low-expression group (n=62) according to the scores of immunohistochemical staining. The clinicopathological parameters and the correlation between c-Jun expression and prognosis of the two groups were analyzed. Comparison on clinicopathological parameters was conducted using Chi-square test and survival analysis was conducted using Kaplan-Meier and Log-rank test.ResultsThe expression of c-Jun in HCC was correlated with HBsAg, alpha-fetoprotein (AFP), tumor size, tumor capsule and tumor vascular invasion (χ2=5.27, 32.68, 4.86, 1.04, 4.62;P<0.05). The 3-, 5-year cumulative survival rate of the high-expression group was respectively 64.14% and 41.20% and those of the low-expression group was respectively 72.04% and 61.21%. The overall survival of the high-expression group was signiifcantly lower than that of the low-expression group (χ2=5.19,P<0.05).Conclusionc-Jun may play an important role in the occurrence and development of HCC and high expression of c-Jun indicates poor prognosis.
