当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2015年
23期
115-116
,共2页
咳嗽变异性哮喘%孟鲁司特%布地奈德%酮替芬
咳嗽變異性哮喘%孟魯司特%佈地奈德%酮替芬
해수변이성효천%맹로사특%포지내덕%동체분
Cough variant asthma%Montelukast%Budesonide%Ketotifen
目的 分析孟鲁司特辅助布地奈德、酮替芬治疗咳嗽变异性哮喘的疗效及安全性.方法 选取咳嗽变异性哮喘患者76例,完全随机地分为观察组和对照组,每组38例.对照组予以布地奈德400μg/d,分2次吸入,酮替芬1 mg/d,分2次口服,观察组在此基础上予以孟鲁司特治疗,4 mg/d,1次口服.观察2组患者治疗后的总有效率,对比治疗前后2组患者第1秒末用力呼气容积(FEV1)、FEV1/用力肺活量(FVC).结果 治疗后总有效率观察组为94.7%(36/38)明显高于对照组76.3%(29/38),差异有统计学意义(P<0.05);2组第1秒用力呼气容积(FEV 1)、FEV 1/用力肺活量(FVC),观察组明显高于对照组,差异有统计学意义(P<0.05);2组患者均未出现用药后不良反应;随访6个月,观察组复发率(7.9%)明显低于对照组(21.1%),差异有统计学意义(P<0.05).结论 孟鲁司特辅助布地奈德、酮替芬治疗咳嗽变异性哮喘有着较好的临床效果及安全性.
目的 分析孟魯司特輔助佈地奈德、酮替芬治療咳嗽變異性哮喘的療效及安全性.方法 選取咳嗽變異性哮喘患者76例,完全隨機地分為觀察組和對照組,每組38例.對照組予以佈地奈德400μg/d,分2次吸入,酮替芬1 mg/d,分2次口服,觀察組在此基礎上予以孟魯司特治療,4 mg/d,1次口服.觀察2組患者治療後的總有效率,對比治療前後2組患者第1秒末用力呼氣容積(FEV1)、FEV1/用力肺活量(FVC).結果 治療後總有效率觀察組為94.7%(36/38)明顯高于對照組76.3%(29/38),差異有統計學意義(P<0.05);2組第1秒用力呼氣容積(FEV 1)、FEV 1/用力肺活量(FVC),觀察組明顯高于對照組,差異有統計學意義(P<0.05);2組患者均未齣現用藥後不良反應;隨訪6箇月,觀察組複髮率(7.9%)明顯低于對照組(21.1%),差異有統計學意義(P<0.05).結論 孟魯司特輔助佈地奈德、酮替芬治療咳嗽變異性哮喘有著較好的臨床效果及安全性.
목적 분석맹로사특보조포지내덕、동체분치료해수변이성효천적료효급안전성.방법 선취해수변이성효천환자76례,완전수궤지분위관찰조화대조조,매조38례.대조조여이포지내덕400μg/d,분2차흡입,동체분1 mg/d,분2차구복,관찰조재차기출상여이맹로사특치료,4 mg/d,1차구복.관찰2조환자치료후적총유효솔,대비치료전후2조환자제1초말용력호기용적(FEV1)、FEV1/용력폐활량(FVC).결과 치료후총유효솔관찰조위94.7%(36/38)명현고우대조조76.3%(29/38),차이유통계학의의(P<0.05);2조제1초용력호기용적(FEV 1)、FEV 1/용력폐활량(FVC),관찰조명현고우대조조,차이유통계학의의(P<0.05);2조환자균미출현용약후불량반응;수방6개월,관찰조복발솔(7.9%)명현저우대조조(21.1%),차이유통계학의의(P<0.05).결론 맹로사특보조포지내덕、동체분치료해수변이성효천유착교호적림상효과급안전성.
Objective To analyze the effect and safety of montelukast combination budesonide and ketotifen for treatment of cough Variant asthma.Methods 76 patients were divided into montelukast combination budesonide and ketotifen group (observation group) of 38 cases and budesonide and ketotifen group (control group) of 38 cases.The control group received budesonide 400μg/d,twice inhalation,Ketotifen 1mg/d,orally twice.Escape that the experimental group were given montelukast treatment,4mg/d,an oral.Observe after treatment efficiency,Compete two groups before and after treatment the end of thefirst second FEV1/ FVC.Results Observation group patients was obviously superior to the control group patients in general effect (P<0.05); recovery rate of observation group was 97.4% (36/38),higher than control group of 76.3% (29/38) (P<0.05).FEV1 and FEV1/FVC of observation group were higher than control group (P<0.05).There is no complication emergence in two groups.Follow two groups for six months,the recurrence rate in the observation group was7.9% which was significantly lower than the control group's (21.1%),the results were statistically significant difference (P<0.05).Conclusion Effect of montelukast combination budesonide and ketotifen in the treatment of cough variant asthma is better,and it is safe enough to patients.
