CAJ | 학술논문

目的：探讨系统性红斑狼疮伴中重度血小板减少患者的临床特征。方法：收集20例系统性红斑狼疮伴中重度血小板减少患者的临床资料，并与20例血小板正常的系统性红斑狼疮患者对比，比较两组患者实验室检查结果、临床症状和体征及疾病活动度的差异。结果：两组患者在发热、皮疹、关节炎等临床症状和体征，抗ds-DNA、抗NUC、抗HIS、抗U1RNP、抗SSA、抗SSB、抗C1q抗体阳性率及疾病活动度等方面比较，差异无统计学意义（P>0.05）；但系统性红斑狼疮伴中重度血小板减少患者白细胞计数、血红蛋白浓度及补体C3水平更低，抗磷脂抗体阳性率更高，差异有统计学意义（P<0.05）。结论：系统性红斑狼疮伴中重度血小板减少患者较系统性红斑狼疮血小板正常患者白细胞计数、血红蛋白浓度及补体C3水平更低，抗磷脂抗体阳性率更高。
목적：탐토계통성홍반랑창반중중도혈소판감소환자적림상특정。방법：수집20례계통성홍반랑창반중중도혈소판감소환자적림상자료，병여20례혈소판정상적계통성홍반랑창환자대비，비교량조환자실험실검사결과、림상증상화체정급질병활동도적차이。결과：량조환자재발열、피진、관절염등림상증상화체정，항ds-DNA、항NUC、항HIS、항U1RNP、항SSA、항SSB、항C1q항체양성솔급질병활동도등방면비교，차이무통계학의의（P>0.05）；단계통성홍반랑창반중중도혈소판감소환자백세포계수、혈홍단백농도급보체C3수평경저，항린지항체양성솔경고，차이유통계학의의（P<0.05）。결론：계통성홍반랑창반중중도혈소판감소환자교계통성홍반랑창혈소판정상환자백세포계수、혈홍단백농도급보체C3수평경저，항린지항체양성솔경고。
Objective:To investigate the clinical characteristics of systemic lupus erythematosus with moderate or severe thrombocytopenia.Methods:Clinical data of 20 cases of systemic lupus erythematosus with moderate or severe thrombocytopenia were collected,which were compared with another 20 cases of system lupus erythematosus with normal platelets on the aspects of laboratory findings,clinical symptoms,signs,and the differences of disease activity.Results:On the aspects of clinical symptoms and signs such as fever,rash and arthritis,anti ds-DNA,anti NUC,anti HIS,anti U1RNP,anti SSA,anti SSB,anti C1q antibodies positive rate and disease activity,the differences between the two groups were not statistically signiifcant (P>0.05),but for those of systemic lupus erythematosus with medium or severe thrombocytopenia,white blood cell count,hemoglobin concentration and complement C3 concentration were lower,and the positive rate of anti phospholipid antibody was higher,the difference being statistically signiifcant (P<0.05).Conclusion:For patients with systemic lupus erythematosus with moderate or severe thrombocytopenia,white blood cell count,hemoglobin concentration and complement C3 concentration were lower,and the positive rate of anti phospholipid antibody was higher than those with normal platelets.