CAJ | 학술논문

目的：探讨肾脏肿瘤 MVD、 VEGF 的表达及其相关性。方法将28例肾脏肿瘤病例（经手术病理证实21例肾细胞癌、7例良性肿瘤）肿瘤组织进行常规石蜡切片，片厚5μm，采用免疫组织化学 SP 法进行染色。显微镜下计数 VEGF表达阳性细胞和 MVD。利用 SPSS 13．0统计软件采用 t 检验和 Spearman 相关分析法进行统计分析。结果肾细胞癌组织的MVD、 VEGF 表达均高于良性肾脏肿瘤，有统计学意义。肾细胞癌及肾脏良性肿瘤的 MVD 与 VEGF 表达在统计学上呈正相关。结论肾细胞癌血管生成活跃， MVD、 VEGF 表达与肾细胞癌的生长、转移有密切关系。
목적：탐토신장종류 MVD、 VEGF 적표체급기상관성。방법장28례신장종류병례（경수술병리증실21례신세포암、7례량성종류）종류조직진행상규석사절편，편후5μm，채용면역조직화학 SP 법진행염색。현미경하계수 VEGF표체양성세포화 MVD。이용 SPSS 13．0통계연건채용 t 검험화 Spearman 상관분석법진행통계분석。결과신세포암조직적MVD、 VEGF 표체균고우량성신장종류，유통계학의의。신세포암급신장량성종류적 MVD 여 VEGF 표체재통계학상정정상관。결론신세포암혈관생성활약， MVD、 VEGF 표체여신세포암적생장、전이유밀절관계。
Objective To discuss the expression of MVD and VEGF in the kidney tumor and its correlation.Methods This study included 28 cases in total which were all proved by pathology (21 cases with renal cell carcinoma, 7 cases with benign kidney tumor).Paraffin sections (5 μm) of the excised tumor were stained with the method of streptavidin peroxidase (SP).The VEGF and MVD of each section were quantified.The data were analyzed by using the SPSS 13.0 package with Independent-sample T test and the Spearman correlation method.Results The expressions of MVD and VEGF in the renal cell carcinoma were higher than those in the benign kidney tumor, with statistically significant difference.There are positive correlation between MVD and VEGF in the renal cell carcinoma and the benign kidney tumor.Conclusion The vessel-generation in the renal cell carcinoma is active.The expression of MVD and VEGF is closely related with the growth and metastasis of renal cell carcinoma.