CAJ | 학술논문

目的：观察苦参注射液辅助选择性动脉栓塞化疗术（transcatheter arterial chemoembolization ，TACE）联合全身化疗治疗结肠癌肝转移的疗效及毒副反应。方法86例结肠癌肝转移患者，均给予 TACE 联合全身化疗，其中48例加用复方苦参注射液静脉滴注（苦参组）。比较苦参组与另38例 TACE 联合全身化疗（联合组）近期疗效及治疗后呕吐反应、腹痛、肝功能。结果术后2月，两组总有效率及疾病控制率比较，差异无统计学意义（P ＞0．05）。苦参组术后24小时呕吐及腹痛症状明显轻于联合组，术后1周谷丙转氨酶（ALT）和总胆红素（TB）明显优于联合组，差异均有统计学意义（P ＜0．05）。结论苦参静脉滴注可以明显减轻 TACE 全身化疗后的呕吐及腹痛，减轻 TACE 的肝脏毒副作用。
목적：관찰고삼주사액보조선택성동맥전새화료술（transcatheter arterial chemoembolization ，TACE）연합전신화료치료결장암간전이적료효급독부반응。방법86례결장암간전이환자，균급여 TACE 연합전신화료，기중48례가용복방고삼주사액정맥적주（고삼조）。비교고삼조여령38례 TACE 연합전신화료（연합조）근기료효급치료후구토반응、복통、간공능。결과술후2월，량조총유효솔급질병공제솔비교，차이무통계학의의（P ＞0．05）。고삼조술후24소시구토급복통증상명현경우연합조，술후1주곡병전안매（ALT）화총담홍소（TB）명현우우연합조，차이균유통계학의의（P ＜0．05）。결론고삼정맥적주가이명현감경 TACE 전신화료후적구토급복통，감경 TACE 적간장독부작용。
Objective To observe the clinical effect and toxicity of transcatheter arterial chemoembolization ( TACE) and chemotherapy combined with sophora injection in the treatment of colorectal cancer liver metastasis .Methods Eight-six patients with colorectal cancer liver metastasis were all treated with TACE and chemotherapy .Of the patients,48 cases were added with sophora in -jection(sophora group).The recent curative effect,the vomiting reaction after treatment,abdominal pain and liver function in the sopho -ra group were compared to another 38 without sophora treatment.Results There was no significant difference in the total effective rate and the disease control rate after 2 months treatment between the two groups .Rate of vomiting and abdominal pain after 24 hours in the sophora group was significantly lighter than that in the control group ,and ALT and TB in the sophora group was better than that in the control group after 2 weeks(all P <0.05).Conclusion Sophora intravenous infusion can significantly reduce vomiting and abdominal pain caused by TACE and chemotherapy ,and protects the liver lesion of TACE .