CAJ | 학술논문

目的：比较羟考酮缓释片与吗啡即释片用于癌症患者中度疼痛滴定的疗效。方法中度癌症疼痛数字分级法（NRS）评分为4～6分的阿片非耐受的癌痛患者60例，采用随机数字表法分为两组各30例，羟考酮组给予羟考酮缓释片10 mg q12 h，痛时给予吗啡即释片解救；吗啡组给予吗啡即释片5 mg q 4 h。评估两组患者24小时疼痛控制情况以及1、12、24 h疼痛缓解率和不良反应发生情况。结果羟考酮组1、12、24 h 疼痛缓解率分别为93％、97％和100％，吗啡组疼痛缓解率为90％、97％和100％，两组滴定镇痛效果比较，差异无统计学意义（P ＞0．05）。12 h 及24 h 内羟考酮组给药次数少于吗啡组。结论羟考酮控释片与吗啡即释片用于癌症患者中度疼痛滴定疗效相近，但用药次数羟考酮优于吗啡。
목적：비교간고동완석편여마배즉석편용우암증환자중도동통적정적료효。방법중도암증동통수자분급법（NRS）평분위4～6분적아편비내수적암통환자60례，채용수궤수자표법분위량조각30례，간고동조급여간고동완석편10 mg q12 h，통시급여마배즉석편해구；마배조급여마배즉석편5 mg q 4 h。평고량조환자24소시동통공제정황이급1、12、24 h동통완해솔화불량반응발생정황。결과간고동조1、12、24 h 동통완해솔분별위93％、97％화100％，마배조동통완해솔위90％、97％화100％，량조적정진통효과비교，차이무통계학의의（P ＞0．05）。12 h 급24 h 내간고동조급약차수소우마배조。결론간고동공석편여마배즉석편용우암증환자중도동통적정료효상근，단용약차수간고동우우마배。
Objective To compare the titration curative effect between oxycodone and morphine release tablets for moderate pain of cancer patients.Methods Sixty opioid intolerance patients whose moderate cancer pain classification (NRS)score were 4 ~6 were divided into oxycodone and morphine groups using a random number table method ,30 cases in each group.The oxycodone group was given oxycodone controlled -release tablets 10 mg q12 h and morphine immediate release tablets were given to rescue when patient pained.The morphine group was given morphine immediate release tablets (5 mg)q 4 h.The pain relief and adverse reactions of 24 hours and at 1,12 and 24 h were compared between the two groups .Results The pain remission rate at 1,12 and 24 h in the oxycodo-ne group were 93%,97% and 100%,respectively while the pain relief rate in the morphine group was 90%,97% and 100%,respec-tively.There was no significant difference in the titration analgesia between the two groups (P >0.05).The administration time in the oxycodone group was less than that in the morphine group .Conclusion The titration effect of oxycodone controlled release tablets and morphine immediate release tablets for cancer patients with moderate pain is the same .However,the times of drug administration in the oxycodone group was less than that in the morphine group .