风湿病与关节炎
風濕病與關節炎
풍습병여관절염
Rheumatism and Arthritis
2015年
8期
15-17,23
,共4页
关节炎,类风湿%抗CCP抗体%肺间质性病变%HRCT%半定量评分
關節炎,類風濕%抗CCP抗體%肺間質性病變%HRCT%半定量評分
관절염,류풍습%항CCP항체%폐간질성병변%HRCT%반정량평분
arthritis,rheumatoid%anti CCP antibodies%interstitial lung disease%HRCT%semi quantitative score
目的：探讨抗环瓜氨酸肽（抗CCP）抗体与类风湿关节炎患者合并肺间质性病变的相关性。方法：选取75例RA患者，所有患者均行胸部HRCT检查，对肺间质性病变进行半定量评分；采用酶联免疫吸附法测定抗CCP抗体（阴性参考区间为0～5 RU·mL-1），按照其定性结果进行分组。观察抗CCP抗体阴性组及阳性组间肺间质性病变的评分有无差异。结果：抗CCP抗体阳性组与阴性组比较，各影像学表现出现的频次差异无统计学意义（P>0.05）；但抗CCP抗体与弥漫性肺间质性病变间有相关趋势（P=0.061）。抗CCP抗体阳性组肺间质性病变的半定量评分高于阴性组（平均秩序为40.43和28.30，P<0.05）。结论：抗CCP抗体与类风湿关节炎肺间质性病变相关，抗体阳性者病变较阴性者重。
目的：探討抗環瓜氨痠肽（抗CCP）抗體與類風濕關節炎患者閤併肺間質性病變的相關性。方法：選取75例RA患者，所有患者均行胸部HRCT檢查，對肺間質性病變進行半定量評分；採用酶聯免疫吸附法測定抗CCP抗體（陰性參攷區間為0～5 RU·mL-1），按照其定性結果進行分組。觀察抗CCP抗體陰性組及暘性組間肺間質性病變的評分有無差異。結果：抗CCP抗體暘性組與陰性組比較，各影像學錶現齣現的頻次差異無統計學意義（P>0.05）；但抗CCP抗體與瀰漫性肺間質性病變間有相關趨勢（P=0.061）。抗CCP抗體暘性組肺間質性病變的半定量評分高于陰性組（平均秩序為40.43和28.30，P<0.05）。結論：抗CCP抗體與類風濕關節炎肺間質性病變相關，抗體暘性者病變較陰性者重。
목적：탐토항배과안산태（항CCP）항체여류풍습관절염환자합병폐간질성병변적상관성。방법：선취75례RA환자，소유환자균행흉부HRCT검사，대폐간질성병변진행반정량평분；채용매련면역흡부법측정항CCP항체（음성삼고구간위0～5 RU·mL-1），안조기정성결과진행분조。관찰항CCP항체음성조급양성조간폐간질성병변적평분유무차이。결과：항CCP항체양성조여음성조비교，각영상학표현출현적빈차차이무통계학의의（P>0.05）；단항CCP항체여미만성폐간질성병변간유상관추세（P=0.061）。항CCP항체양성조폐간질성병변적반정량평분고우음성조（평균질서위40.43화28.30，P<0.05）。결론：항CCP항체여류풍습관절염폐간질성병변상관，항체양성자병변교음성자중。
Objective:To investigate the correlation between anti CCP antibody and rheumatoid arthri-tis with interstitial lung disease.Methods:75 patients with rheumatoid arthritis were underwent chest HRCT to get semiquantitative scores.Enzyme-linked immunosorbent assay(ELISA)was used to determine the CCP antibody (The negative reference interval is 0~5 RU·mL-1) and the patients were grouped according to the results. The differences of scores of interstitial lung disease between the negative and positive groups were observed. Results:There was no signiifcant difference in the frequency of CCP(P>0.05),but the anti CCP antibody had a correlation with diffuse interstitial lung disease(P=0.061).The semi quantitative score of CCP in the positive group was higher than that in the negative group(the average order was 40.43 and 28.30,P<0.05).Conclu-sion:There is a correlation between anti CCP antibody and rheumatoid arthritis with interstitial lung disease,and pathological changes in positive patients are more serious than those in negative ones.
