CAJ | 학술논문

目的：探讨莫沙必利联合铝碳酸镁治疗胆汁反流性胃炎（RBG）的临床疗效。方法收集2010年10月至2014年10月本院收治的 RBG 患者60例，随机分为对照组和联合治疗组，对照组给予莫沙必利治疗，联合治疗组给予莫沙必利联合铝碳酸镁治疗，分别比较患者的治疗疗效、胆汁反流情况、临床症状评分和不良反应发生状况。结果联合治疗组患者治疗有效率（93．8％）明显高于对照组（71．4％），两者差异有统计学意义（χ2＝7．090； P＜0．05）；联合治疗组患者反流次数、＞5 min 的反流次数、反流总时间百分比指标值均小于对照组（t＝－4．072，－8．416，－5．256； P＜0．01），恶心、腹痛和腹胀的评分均低于对照组（t＝－9．247，－2．833，－8．390； P＜0．05），但两组最长反流时间和呕吐评分的差异无统计学意义（t＝－1．872，1．767； P＞0．05）；联合治疗组不良反应发生率6．25％（2／32）和对照组不良反应发生率10．7％（3／28）差异无统计学意义（χ2＝3．202； P＞0．05）。结论莫沙必利联合碳酸铝镁既能结合胆汁反流物，又能促进胃肠动力，且不良反应发生少，适用于 RBG 患者的治疗。
목적：탐토막사필리연합려탄산미치료담즙반류성위염（RBG）적림상료효。방법수집2010년10월지2014년10월본원수치적 RBG 환자60례，수궤분위대조조화연합치료조，대조조급여막사필리치료，연합치료조급여막사필리연합려탄산미치료，분별비교환자적치료료효、담즙반류정황、림상증상평분화불량반응발생상황。결과연합치료조환자치료유효솔（93．8％）명현고우대조조（71．4％），량자차이유통계학의의（χ2＝7．090； P＜0．05）；연합치료조환자반류차수、＞5 min 적반류차수、반류총시간백분비지표치균소우대조조（t＝－4．072，－8．416，－5．256； P＜0．01），악심、복통화복창적평분균저우대조조（t＝－9．247，－2．833，－8．390； P＜0．05），단량조최장반류시간화구토평분적차이무통계학의의（t＝－1．872，1．767； P＞0．05）；연합치료조불량반응발생솔6．25％（2／32）화대조조불량반응발생솔10．7％（3／28）차이무통계학의의（χ2＝3．202； P＞0．05）。결론막사필리연합탄산려미기능결합담즙반류물，우능촉진위장동력，차불량반응발생소，괄용우 RBG 환자적치료。
Objective To evaluate the clinical efficacy of combined usage of mosapride and hydrotclcire for bile reflux gastritis. Methods 60 cases of RBG patients treated in our hospital from October 2010 to October 2014 were randomly divided into control group given mosapride and combined treatment group given mosapride and hydrotclcire.Such treatment results as clinical efficacy, bile reflux, clinical symptom scores and adverse reactions were compared between these two groups.Results The treatment efficiency of combined treatment group (93.8%) was significantly higher than that of the control group (71.4%).The difference was statistically significant (χ2 =7.090, P<0.05); In the combined treatment group, the reflux episodes, reflux episodes ( >5 min) and the per-centile index of total reflux time were lower than the control group (t =-4.072, -8.416, -5.256, P<0.01).Also the nausea scores, abdominal pain scores, and bloating scores were lower than the control group (t =-9.247, -2.833, 8.390, P<0.05). However, there was no difference between the two groups in the longest reflux time and vomiting scores (t =-1.872, 1.767, P>0.05), there was no statistically significant difference in incidence of adverse reaction (χ2 =3.202, P>0.05).Conclusions The combination usage of mosapride and hydrotclcire can conjugate bile reflux, promote gastrointestinal motility and cause fewer adverse re-actions, and therefore it is applicable for RBG patients.