CAJ | 학술논문

目的：探讨丹红注射液联合阿托伐他汀辅助治疗短暂性脑缺血发作疗效与机制。方法：短暂性脑缺血发作患者80例根据随机抽签原则分为治疗组与对照组，每组40例，两组都给予常规基础治疗，对照组口服阿托伐他汀钙片，治疗组在对照组治疗的基础上给予丹红注射液注射治疗，两组都治疗14d 。结果：治疗组的总有效率为97．5％，对照组的总有效率为85．0％，治疗组明显高于对照组（P＜0．05）。两组治疗后的血清 TC 、LDL‐C 值都明显下降，而HDL‐C 值明显上升（P＜0．05），同时治疗后治疗组的血清 TC 、LDL‐C 、HDL‐C 值与对照组对比差异也有统计学意义（P＜0．05）。两组治疗后的全血高切粘度、低切粘度与血浆粘度都呈明显下降的趋势（P＜0．05），同时治疗后治疗组的全血高切粘度、低切粘度与血浆粘度明显低于对照组（P＜0．05）。结论：丹红注射液联合阿托伐他汀辅助治疗短暂性脑缺血发作能有效提高治疗疗效，其作用机制可能在于合理调节机体内血脂含量与促进血液流动。
목적：탐토단홍주사액연합아탁벌타정보조치료단잠성뇌결혈발작료효여궤제。방법：단잠성뇌결혈발작환자80례근거수궤추첨원칙분위치료조여대조조，매조40례，량조도급여상규기출치료，대조조구복아탁벌타정개편，치료조재대조조치료적기출상급여단홍주사액주사치료，량조도치료14d 。결과：치료조적총유효솔위97．5％，대조조적총유효솔위85．0％，치료조명현고우대조조（P＜0．05）。량조치료후적혈청 TC 、LDL‐C 치도명현하강，이HDL‐C 치명현상승（P＜0．05），동시치료후치료조적혈청 TC 、LDL‐C 、HDL‐C 치여대조조대비차이야유통계학의의（P＜0．05）。량조치료후적전혈고절점도、저절점도여혈장점도도정명현하강적추세（P＜0．05），동시치료후치료조적전혈고절점도、저절점도여혈장점도명현저우대조조（P＜0．05）。결론：단홍주사액연합아탁벌타정보조치료단잠성뇌결혈발작능유효제고치료료효，기작용궤제가능재우합리조절궤체내혈지함량여촉진혈액류동。
Objective :To investigate the efficacy and mechanism of Danhong injection combined with atorvas ‐tatin for adjuvant treating transient ischemic attack .Methods :80 transient ischemic attack patients patients based on the principle of a random draw were equally divided into the treatment group and the control group ,all patients were given on a regular basis ,the control group were treated with atorvastatin calcium ,the treatment group were treated by the Dan‐hong injection combined with atorvastatin .The cycles were 14 days of treatment in both groups .Results :The total effi‐ciency in the treatment group and the control group owere 97 .5% and 85 .0% respectively that the total efficiency in the treatment group were significantly higher (P< 0 .05) .After treatment ,the serum TC ,LDL‐C values were significantly decreased ,while the HDL‐C values were significantly increased ,compared to the difference were statistically significant (P< 0 .05) ,while the serum TC ,LDL‐C ,HDL ‐C values after treatment in the treatment group were significant differ‐ences compared to the control group(P < 0 .05) .The whole blood high shear viscosity ,low shear viscosity and plasma viscosity in the two groups after treatment were showed clear downward trend (P< 0 .05) ,while high shear whole blood viscosity ,low shear viscosity and plasma viscosity in the treatment group after treatment were significantly lower than those in the control group (P < 0 .05) .Conclusion :Danhong injection combined with atorvastatin for adjuvant treating transient ischemic attack can effectively improve the therapeutic efficacy of its mechanism of action is reasonably possible to adjust the body lipid content and promote blood flow .