CAJ | 학술논문

目的：比较使用莫沙比利和替普瑞酮对 FD 患者的治疗效果。方法前瞻性临床比较研究与随机分配在进行的试验。1042例呈现 FD 症状的胃胀或上腹部疼痛的患者被录取。初始内镜评价后，使用莫沙比利5 mg tid 或替普瑞酮替普瑞酮胶囊50 mg tid 开始治疗。评估上腹疼和腹胀的严重程度和频率，健康相关的生活质量（HR －QOL），和病人的对药物依从性。结果在研究的1027名患者中经内窥镜检查90例（9％）有器质性病变。在那些用内窥镜检测没有任何特定的病变，开始药物治疗前，264例（30％）胃肠道症状在一个星期之内消除。618仍有症状的患者被随机使用莫沙比利（n ＝311）或替普瑞酮（n＝307）治疗。经两周的治疗，莫沙比利相比替普瑞酮有显著疗效。莫沙比利也改善 HR－QOL，62％的病人喜欢用莫沙比利治疗，而只有27．6％的病人接受替普瑞酮治疗。结论为改善 FD 症状用内镜检查病人是有用的。在莫沙比利和替普瑞酮的安全性和有效性上比较，患者更愿意接受前者。
목적：비교사용막사비리화체보서동대 FD 환자적치료효과。방법전첨성림상비교연구여수궤분배재진행적시험。1042례정현 FD 증상적위창혹상복부동통적환자피록취。초시내경평개후，사용막사비리5 mg tid 혹체보서동체보서동효낭50 mg tid 개시치료。평고상복동화복창적엄중정도화빈솔，건강상관적생활질량（HR －QOL），화병인적대약물의종성。결과재연구적1027명환자중경내규경검사90례（9％）유기질성병변。재나사용내규경검측몰유임하특정적병변，개시약물치료전，264례（30％）위장도증상재일개성기지내소제。618잉유증상적환자피수궤사용막사비리（n ＝311）혹체보서동（n＝307）치료。경량주적치료，막사비리상비체보서동유현저료효。막사비리야개선 HR－QOL，62％적병인희환용막사비리치료，이지유27．6％적병인접수체보서동치료。결론위개선 FD 증상용내경검사병인시유용적。재막사비리화체보서동적안전성화유효성상비교，환자경원의접수전자。
Objective To compare the clinical efficacy of mosapride and teprenone in treating patients with functional dyspepsia (FD).Methods This is a prospective clinical comparative study with randomized allocation trials.1 042 patients with symptoms of FD, either gastric stasis ( GSS) and/or epigastric pain (EPS), were selected.After initial endoscopic evaluation, patients took ei-ther mosapride 5 mg tid or teprenone 50 mg tid.Severity and frequency of GSS and EPS, health-related quality of life (HR-QOL), and patients'compliance to medication were evaluated.Results Of the 1027 patients, organic lesions were found examined by en-doscopy in 90 patients (9%).Among those without any speci c lesions detected by endoscopy , gastrointes-tinal symptoms were re-solved within one week after the endoscopy in 264 (28%) patients before initiating medication.618 patients who remained symptomat-ic were randomized to medication either with mosapride (n=311) or teprenone (n=307).Compared with teprenone, two-week treat-ment with mosapride signi cantly improvedGSS and EPS.Mosapride also improved HR-QOL.62% of patients preferred to be treat-ment with mosapride, while only 27.6% of patients favored the treatment with teprenone.Co nclusions Endoscopic examination proves to be useful in improving FD symptom.Patients prefer mosapride to teprenone for its safety and efficacy.