CAJ | 학술논문

目的：探讨氨溴索序贯治疗慢性阻塞性肺疾病（简称慢阻肺）急性加重期的临床疗效。方法2014年1～12月在我院治疗的慢阻肺急性加重期患者98例，按随机数字表法分为序贯组和对照组各49例，对照组行常规治疗，序贯组在常规治疗基础上给予氨溴索序贯治疗，比较两组临床疗效。结果序贯组治疗后第1秒用力呼气容积（FEV1）、用力肺活量（FVC）、FEV1／FVC、最大峰流速值（PEF）、pH、动脉血氧分压（PaO2）、动脉二氧化碳分压（PaCO2）、血氧分压[Pbt（O2）]、氧合指数[Pbt（O2）／FiO2]、气道峰压（PIP）、气道阻力（RAW）、肺顺应性（CL）均优于对照组（P ＜0．05），总有效率高于对照组（P ＜0．05）。结论慢阻肺急性加重期应用氨溴索序贯治疗有一定的优势，具有临床推广应用价值。
목적：탐토안추색서관치료만성조새성폐질병（간칭만조폐）급성가중기적림상료효。방법2014년1～12월재아원치료적만조폐급성가중기환자98례，안수궤수자표법분위서관조화대조조각49례，대조조행상규치료，서관조재상규치료기출상급여안추색서관치료，비교량조림상료효。결과서관조치료후제1초용력호기용적（FEV1）、용력폐활량（FVC）、FEV1／FVC、최대봉류속치（PEF）、pH、동맥혈양분압（PaO2）、동맥이양화탄분압（PaCO2）、혈양분압[Pbt（O2）]、양합지수[Pbt（O2）／FiO2]、기도봉압（PIP）、기도조력（RAW）、폐순응성（CL）균우우대조조（P ＜0．05），총유효솔고우대조조（P ＜0．05）。결론만조폐급성가중기응용안추색서관치료유일정적우세，구유림상추엄응용개치。
Objective To study the clinical effect of ambroxol sequential therapy for the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Methods Ninety-eight patients with AECOPD treated in our hospital from January 2014 to December 2014 were randomly divided into sequential and control groups ,49 in each group.The control group was treated with conventional therapy while the sequential group was treated with ambroxol sequential therapy on the basis of the conventional therapy . The clinical effects were compared between the two groups .Results After treatment,all indexes such as forced expiratory volume in the first second(FEV1),vital capacity(FVC),ratio of FEV1 /FVC,maximum peak velocity value(PVF),pH,PaO2 ,PaCO2 ,Pbt(O2 ), Pbt(O2 ) /FiO2 ,airway peak pressure(PIP),airway resistance(RAW),and lung compliance(CL)in the sequential group were all better than that in the control group (P <0.05).The total effect in the sequential group was higher than that in the control group (P <0.05). Conclusion The ambroxol sequential treatment has certain advantages in the treatment of AECOPD .It is valuable for the clinical use .