CAJ | 학술논문

目的：N－乙基乙酰胺是重要的化工中间体，在医药、农药等领域得到比较广泛的应用。采用 Al2 O3和 SiO2组合物作催化剂，以乙酸乙酯、乙胺为原料合成N －乙基乙酰胺。方法反应温度、反应时间和催化剂对反应的影响，最佳工艺条件为 Al2 O3和 SiO2组合物（87∶13）催化下40℃水浴反应24h ，室温静置48 h。结果产品收率达61．62％，产品纯度99．2％（HPLC 归一化法），产物结构经1 HNMR 表征。结论改进后的工艺简单可行，适合实验室简易合成。
목적：N－을기을선알시중요적화공중간체，재의약、농약등영역득도비교엄범적응용。채용 Al2 O3화 SiO2조합물작최화제，이을산을지、을알위원료합성N －을기을선알。방법반응온도、반응시간화최화제대반응적영향，최가공예조건위 Al2 O3화 SiO2조합물（87∶13）최화하40℃수욕반응24h ，실온정치48 h。결과산품수솔체61．62％，산품순도99．2％（HPLC 귀일화법），산물결구경1 HNMR 표정。결론개진후적공예간단가행，괄합실험실간역합성。
Objective As a kind of important chemical intermediate, N-Ethylacetamide has been widely applied to medicine, pesticide and so on.N-Ethylacetamide was synthesized from ethyl acetate, ethylamine and composition of Al2 O3 -SiO2 as catalyst. Methods The effects of reaction temperature, reaction time, catalyst on the reaction product yield were evaluated, and the optimum reaction conditions were: water bath 24 h at 40℃ and at room temperature for 48 h.Results Under the optimum conditions, yield reached to 61.62% with the purity of product amounting up to 99% (HPLC, normalization method).The structure of product was manifested by 1HNMR spectrometry.Conclusions The improved process is simple and convenient, and suitable for thelaboratory preparation.