CAJ | 학술논문

皮肌炎、多发性肌炎和散发型包涵体肌炎是临床较为常见的炎性肌病，其发病过程涉及不同的免疫过程。目前的研究认为皮肌炎的发病与补体介导的免疫过程相关，多发性肌炎和包涵体肌炎的是 T 细胞介导的细胞毒免疫过程，除此之外由于 MHCI 高表达所造成的内质网应激也与多发性肌炎和包涵体肌炎的发病密切相关。 miRNA 是在基因转录后水平起调控作用的长度约为21～25 nt 的非编码小 RNA，miRNA 能够调节机体的多种生理过程，其与疾病发生过程有密切相关。本文总结了皮肌炎、多发性肌炎和散发型包涵体肌炎中 miRNA 的特异性表达情况，并分析了不同 miRNA 对三种特发性炎性肌病发病过程中重要蛋白的调控作用，为临床进一步探讨 miRNA 在炎性肌病中的诊断和治疗提供帮助。
피기염、다발성기염화산발형포함체기염시림상교위상견적염성기병，기발병과정섭급불동적면역과정。목전적연구인위피기염적발병여보체개도적면역과정상관，다발성기염화포함체기염적시 T 세포개도적세포독면역과정，제차지외유우 MHCI 고표체소조성적내질망응격야여다발성기염화포함체기염적발병밀절상관。 miRNA 시재기인전록후수평기조공작용적장도약위21～25 nt 적비편마소 RNA，miRNA 능구조절궤체적다충생리과정，기여질병발생과정유밀절상관。본문총결료피기염、다발성기염화산발형포함체기염중 miRNA 적특이성표체정황，병분석료불동 miRNA 대삼충특발성염성기병발병과정중중요단백적조공작용，위림상진일보탐토 miRNA 재염성기병중적진단화치료제공방조。
Dermatomyositis,polymyositis and sporadic inclusion body myositis are the most common subtypes of idiopathic in -flamamatory myopathies(IIMs),which are underlying different inflammatory processes .Although the pathogenesis of IIM ,the occurrence and development of dematomyositis is associated with complement -mediated immunologicprocess ,Polymyositis and inclusion-body myo-sitis are T-cell-mediated cytotoxic processes ,and ER stress due to upregulation of MHC class I antigen expression is also involved in the progresses.MiRNAs,a class of 21 ~25 nt noncoding small RNAs,can regulate gene expression at post -transcriptional level.Dyregulated miRNAs may play important roles in the development of many diseases .In this review we summerized the specific expressed miRNAs in different subtypes of inflamamatory myopathies and analyzed the relationships between miRNAs and key proteins in the processes of these muscular disorders,which may be useful in clinical diagnosis and therapeutic strategies for inflamamatory myopathies .