CAJ | 학술논문

痛风的发病率和患病率在世界范围内呈逐年上升趋势，严重威胁人民健康，给社会带来巨大经济负担。在健康人体内血尿酸处于动态平衡，该平衡打破所致的高尿酸血症，是痛风发生的生化基础；而葡萄糖转运蛋白9（glucose transporter 9，GLUT9）作为一种尿酸盐转运体，对体内尿酸盐稳态的维持有着重要作用。本文就 GLUT9的结构、组织分布、生理功能及其编码基因单核苷酸多态性与血尿酸水平及痛风发病的相关性作一综述。
통풍적발병솔화환병솔재세계범위내정축년상승추세，엄중위협인민건강，급사회대래거대경제부담。재건강인체내혈뇨산처우동태평형，해평형타파소치적고뇨산혈증，시통풍발생적생화기출；이포도당전운단백9（glucose transporter 9，GLUT9）작위일충뇨산염전운체，대체내뇨산염은태적유지유착중요작용。본문취 GLUT9적결구、조직분포、생리공능급기편마기인단핵감산다태성여혈뇨산수평급통풍발병적상관성작일종술。
In the worldwide,the incidence and prevalence of gout have showed an increasing trend year by year ,it threaten to people's health seriously and has brought huge economic burden .In vivo of the healthy human,urate are in dynamic equilibrium,while the urate balance is broken,hyperuricemia is going to be formed and as the biochemical basis for the onset of gout .As a urate transport-er,GLUT9 plays an important role in urate homeostasis in vivo .Here is to make a review on GLUT9's structure,distribution,physiologi-cal function and the relevance between SNP of its coding gene and the incidence of gout or blood uric acid levels .