国际病毒学杂志
國際病毒學雜誌
국제병독학잡지
INTERNATIONAL JOURNAL OF VIROLOGY
2015年
4期
270-273
,共4页
慢性乙型肝炎%两对半检测%HBV-DNA%免疫
慢性乙型肝炎%兩對半檢測%HBV-DNA%免疫
만성을형간염%량대반검측%HBV-DNA%면역
Chronic hepatitis B%Two pairs of semi-detection%HBV-DNA%Immunity
目的 探讨慢性乙型肝炎患者两对半指标变化的监测价值.方法 2012年9月到2014年8月期间,选择在本院传染科进行诊治的110例慢性乙型肝炎患者作为研究对象,都进行了两对半指标检测、HBV-DNA定量检测和免疫指标检测,并且进行了相关性分析.结果 在110例患者中,出现大三阳(HBsAg、HBeAg及HBcAb阳性)32例,占比29.1％;小三阳(HBsAg、HBeAb及HBcAb阳性)38例,占比34.5％,各型模式对比具有差异性(P＜0.05).HBV-DNA定量平均值为(3.26±0.45)×106/ml,其中大三阳与小三阳模式的HBV-DNA定量值明显高于其他模式(P＜0.05).血清IFNγ和IL-4平均值为(18.23±7.14) pg/ml和(25.54±10.44) pg/ml,其中大三阳与小三阳模式的IFNγ和IL-4值明显高于其他模式(P＜0.05).Spersonman相关性分析显示大三阳与小三阳比率与HBV-DNA定量、血清IFNγ和IL-4表达呈现明显正向相关性(P＜0.05).治疗后HBV-DNA转阴89例,转阴率为80.9％.结论 慢性乙型肝炎患者两对半指标监测能有效反映机体的HBV-DNA定量情况与免疫状况,从而判断患者病情变化,指导进行临床治疗.
目的 探討慢性乙型肝炎患者兩對半指標變化的鑑測價值.方法 2012年9月到2014年8月期間,選擇在本院傳染科進行診治的110例慢性乙型肝炎患者作為研究對象,都進行瞭兩對半指標檢測、HBV-DNA定量檢測和免疫指標檢測,併且進行瞭相關性分析.結果 在110例患者中,齣現大三暘(HBsAg、HBeAg及HBcAb暘性)32例,佔比29.1％;小三暘(HBsAg、HBeAb及HBcAb暘性)38例,佔比34.5％,各型模式對比具有差異性(P＜0.05).HBV-DNA定量平均值為(3.26±0.45)×106/ml,其中大三暘與小三暘模式的HBV-DNA定量值明顯高于其他模式(P＜0.05).血清IFNγ和IL-4平均值為(18.23±7.14) pg/ml和(25.54±10.44) pg/ml,其中大三暘與小三暘模式的IFNγ和IL-4值明顯高于其他模式(P＜0.05).Spersonman相關性分析顯示大三暘與小三暘比率與HBV-DNA定量、血清IFNγ和IL-4錶達呈現明顯正嚮相關性(P＜0.05).治療後HBV-DNA轉陰89例,轉陰率為80.9％.結論 慢性乙型肝炎患者兩對半指標鑑測能有效反映機體的HBV-DNA定量情況與免疫狀況,從而判斷患者病情變化,指導進行臨床治療.
목적 탐토만성을형간염환자량대반지표변화적감측개치.방법 2012년9월도2014년8월기간,선택재본원전염과진행진치적110례만성을형간염환자작위연구대상,도진행료량대반지표검측、HBV-DNA정량검측화면역지표검측,병차진행료상관성분석.결과 재110례환자중,출현대삼양(HBsAg、HBeAg급HBcAb양성)32례,점비29.1％;소삼양(HBsAg、HBeAb급HBcAb양성)38례,점비34.5％,각형모식대비구유차이성(P＜0.05).HBV-DNA정량평균치위(3.26±0.45)×106/ml,기중대삼양여소삼양모식적HBV-DNA정량치명현고우기타모식(P＜0.05).혈청IFNγ화IL-4평균치위(18.23±7.14) pg/ml화(25.54±10.44) pg/ml,기중대삼양여소삼양모식적IFNγ화IL-4치명현고우기타모식(P＜0.05).Spersonman상관성분석현시대삼양여소삼양비솔여HBV-DNA정량、혈청IFNγ화IL-4표체정현명현정향상관성(P＜0.05).치료후HBV-DNA전음89례,전음솔위80.9％.결론 만성을형간염환자량대반지표감측능유효반영궤체적HBV-DNA정량정황여면역상황,종이판단환자병정변화,지도진행림상치료.
Objective To investigate the clinical values of dynamic changes of serum markers in patients with chronic hepatitis B.Methods One hundred and tenpatients with chronic hepatitis B were selected as research subjects from the infectious department of our hospital from Sep 2012 to Aug 2014.All samples were tested for HBV serum markers,HBV-DNA as well as quantitative analysis of immune parameters,and the results were analyzed by correlation analysis.Results The detection rate for HBsAg,HBeAg and HBcAb positive patients was 29.1％ and for HBsAg,HBeAb and HBcAb positive patients was 34.5％.There was no significant difference between both types of patients (P ＜ 0.05).The average level of HBV-DNA was (3.26 ± 0.45) × 106 copy/ml.HBV-DNA titers both in HBsAg,HBeAg and HBcAb positive patients and in HBsAg,HBeAb and HBcAb positive patients were significantly higher than other patients (P ＜0.05).The average levels serum IFNγand IL-4 were (18.23 ± 7.14) pg/ml and (25.54 ± 10.44) pg/ml,respectively.The average levels of serum IFNγ and IL-4 of both the HBsAg,HBeAg and HBcAb positive patients and HBsAg,HBeAb and HBcAb positive patients were significantly higher than other patients (P ＜ 0.05).Spersonman correlation analysis showed that the ratio between HBsAg,HBeAg and HBcAb positive patients and HBsAg,HBeAb and HBcAb positive patients was positively related to the quantitative serum IFNγIL-4 expression and HBV-DNA (P ＜ 0.05).After treatment,negative conversion of HBV-DNA occurred in 89 patients with a negative conversion rate of 80.9％.Conclusions Serum markers could be used as effective indicators to reflect HBV-DNA titers and the immune status duringchronic hepatitis B patients monitoring,and to guide treatment.
