CAJ | 학술논문

饥饿激素( ghrelin)是生长激素促分泌素受体的唯一内源性配体，也是唯一可以在外周刺激食欲的激素。 ghrelin在机体食欲、体重、胃肠功能、脂肪代谢、葡萄糖代谢及脂类代谢等生理活动的调节中发挥着重要作用。 ghrelin的酰基化是与其受体结合产生相应生物学效应的前提。本文系统综述了ghrelin在能量代谢中的作用模式与分子机制。
기아격소( ghrelin)시생장격소촉분비소수체적유일내원성배체，야시유일가이재외주자격식욕적격소。 ghrelin재궤체식욕、체중、위장공능、지방대사、포도당대사급지류대사등생리활동적조절중발휘착중요작용。 ghrelin적선기화시여기수체결합산생상응생물학효응적전제。본문계통종술료ghrelin재능량대사중적작용모식여분자궤제。
Ghrelin is the only endogenous ligand of growth hormone secretagogue receptor ( GHSR ) , and is also the only appetite-stimulating hormone in the periphery. Ghrelin plays an important role in the regulation of the appetite, weight, gastrointestinal function, fat metabolism, glucose metabolism, and lipid metabolism, ect. The acidylation of ghrelin plays an essential role in producing the biological effects combining with its receptor. The article summarized that the function patterns and molecular mechanisms of ghrelin in energy metabolism.