中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2015年
4期
528-530
,共3页
机械通气%辅助治疗%手足口病%神经源性肺水肿
機械通氣%輔助治療%手足口病%神經源性肺水腫
궤계통기%보조치료%수족구병%신경원성폐수종
Mechanical ventilation%Adjuvant therapy%Hand,foot and mouth disease%Neurogenic pulmonary edema
目的：探讨机械通气辅助治疗在手足口病并发神经源性肺水肿的临床应用价值。方法选取2008至2013年于本院进行治疗的并发神经源性肺水肿的重症手足口病患儿共85例，所有患儿经临床诊断均确诊为重症手足口病并发神经源性肺水肿。将85例患儿按照入院时所处病程进行分组，分为A组、B组和C组三组，分别为28、28和29例患儿。A组28例患儿入院时处于病程第4天，B组28例患儿入院时所处病程第3天，C组29例患儿入院时所处病程第2天，均在内科综合治疗的基础上联合使用机械通气辅助进行治疗。结果经临床治疗，A组、B组和C组患儿分别治愈16例、20例和24例，治愈率分别为57.14%、71.43%和82.76%。C组患儿的治愈率显著高于A组和B组，且差异具有统计学意义（C组vs A组：χ2=16.354、P=0.000，C组vs B组：χ2=4.545、P=0.033）。B组患儿病死率显著低于A组，差异具有统计学意义（χ2=4.583、P =0.032）。C组患儿的高热、口吐白沫、躁动和肺部啰音等临床主要症状的转归时间和住院时间均显著短于B组和A组，且差异具有统计学意义（P均＜0.005）。结论机械通气辅助治疗联合内科综合治疗重症手足口病并发神经源性肺水肿患儿，早期应用机械通气辅助治疗能够显著地提高患儿的临床治愈率，并显著地缩短患儿的临床症状持续时间和住院时间，降低病死率，具有较高的临床价值。
目的：探討機械通氣輔助治療在手足口病併髮神經源性肺水腫的臨床應用價值。方法選取2008至2013年于本院進行治療的併髮神經源性肺水腫的重癥手足口病患兒共85例，所有患兒經臨床診斷均確診為重癥手足口病併髮神經源性肺水腫。將85例患兒按照入院時所處病程進行分組，分為A組、B組和C組三組，分彆為28、28和29例患兒。A組28例患兒入院時處于病程第4天，B組28例患兒入院時所處病程第3天，C組29例患兒入院時所處病程第2天，均在內科綜閤治療的基礎上聯閤使用機械通氣輔助進行治療。結果經臨床治療，A組、B組和C組患兒分彆治愈16例、20例和24例，治愈率分彆為57.14%、71.43%和82.76%。C組患兒的治愈率顯著高于A組和B組，且差異具有統計學意義（C組vs A組：χ2=16.354、P=0.000，C組vs B組：χ2=4.545、P=0.033）。B組患兒病死率顯著低于A組，差異具有統計學意義（χ2=4.583、P =0.032）。C組患兒的高熱、口吐白沫、躁動和肺部啰音等臨床主要癥狀的轉歸時間和住院時間均顯著短于B組和A組，且差異具有統計學意義（P均＜0.005）。結論機械通氣輔助治療聯閤內科綜閤治療重癥手足口病併髮神經源性肺水腫患兒，早期應用機械通氣輔助治療能夠顯著地提高患兒的臨床治愈率，併顯著地縮短患兒的臨床癥狀持續時間和住院時間，降低病死率，具有較高的臨床價值。
목적：탐토궤계통기보조치료재수족구병병발신경원성폐수종적림상응용개치。방법선취2008지2013년우본원진행치료적병발신경원성폐수종적중증수족구병환인공85례，소유환인경림상진단균학진위중증수족구병병발신경원성폐수종。장85례환인안조입원시소처병정진행분조，분위A조、B조화C조삼조，분별위28、28화29례환인。A조28례환인입원시처우병정제4천，B조28례환인입원시소처병정제3천，C조29례환인입원시소처병정제2천，균재내과종합치료적기출상연합사용궤계통기보조진행치료。결과경림상치료，A조、B조화C조환인분별치유16례、20례화24례，치유솔분별위57.14%、71.43%화82.76%。C조환인적치유솔현저고우A조화B조，차차이구유통계학의의（C조vs A조：χ2=16.354、P=0.000，C조vs B조：χ2=4.545、P=0.033）。B조환인병사솔현저저우A조，차이구유통계학의의（χ2=4.583、P =0.032）。C조환인적고열、구토백말、조동화폐부라음등림상주요증상적전귀시간화주원시간균현저단우B조화A조，차차이구유통계학의의（P균＜0.005）。결론궤계통기보조치료연합내과종합치료중증수족구병병발신경원성폐수종환인，조기응용궤계통기보조치료능구현저지제고환인적림상치유솔，병현저지축단환인적림상증상지속시간화주원시간，강저병사솔，구유교고적림상개치。
Objective To investigate the clinical application value of mechanical ventilation adjuvant therapy on hand, foot and mouth disease (HFMD) complicated with neurogenic pulmonary edema. Methods Total of 85 cases with HFMD complicated with neurogenic pulmonary edema were collected in our hospital from 2008 to 2013. The 85 cases were divided into group A, group B and group C, with 28, 28 and 29 cases, respectively. Group A were in the course of the fourth days, group B were in the course of the third days and the group C were in the course of second days. All cases in the three groups were given the comprehensive treatment of internal department combined with mechanical ventilation. Results Through clinical treatment, there were 16, 20 and 24 cases were cured, the cure rate were 57.14%, 71.43%and 82.76%, respectively. The cure rate of group C were signiifcantly higher than that of group A and group B (group C vs group A:χ2=16.354, P=0.000;group C vs group B:χ2=4.545, P=0.033). The mortality of cases in group B was signiifcantly lower than that of group A (χ2=4.583, P=0.032). The prognosis time of taking early mechanical ventilation combined with comprehensive treatment of cases in group C in department of internal medicine such as high fever, foaming at the mouth, restlessness and lung rale and the their length of stay were all shorter than that of group B and group A (P all<0.05). Conclusions The mechanical ventilation adjuvant therapy combined with neurogenic pulmonary edema treatment of internal department on children with serious HFMD complicated with neurogenic pulmonary edema could signiifcantly enhance the clinical cure rate and shorten the duration of clinical symptoms and length of stay and reduce mortality, which had quite high clinical value.
