中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2015年
4期
544-547
,共4页
喉癌%术后感染%肿瘤复发%相关因素
喉癌%術後感染%腫瘤複髮%相關因素
후암%술후감염%종류복발%상관인소
Laryngeal carcinoma%Postoperative infection%Tumor recurrence%Relate factors
目的：分析喉癌术后感染相关因素及与局部肿瘤复发的相关性。方法回顾性分析于本院行手术治疗的160例喉癌患者的临床资料，记录术后感染的部位及病原菌种类；采用Logistic回归方程计算喉癌术后感染高危因素。统计喉癌术后感染者的局部复发率，分析喉癌术后感染与局部肿瘤复发的相关性。结果160例喉癌手术患者中发生感染共30例，感染率为18.75%；术后感染部位主要是切口，其次分别为呼吸道和咽部等。30例术后感染者中共分离出27株病原菌，其中革兰阳性菌12株（44.44%），革兰阴性菌15株（55.56%）。多因素分析显示，手术时间、临床分期和全喉切除术是导致喉癌术后感染的主要危险因素（P均＜0.05）。术后随访6个月，160例患者中有18例局部复发，复发率为11.25%；其中术后感染者局部复发8例，复发率26.67%（8/30）；无感染者术后局部复发率为7.69%（10/130），两组相比差异具有统计学意义（χ2=12.659、P=0.000）。结论导致喉癌术后感染的主要危险因素为手术时间、临床分期和手术类型；术后感染者局部肿瘤复发率更高。
目的：分析喉癌術後感染相關因素及與跼部腫瘤複髮的相關性。方法迴顧性分析于本院行手術治療的160例喉癌患者的臨床資料，記錄術後感染的部位及病原菌種類；採用Logistic迴歸方程計算喉癌術後感染高危因素。統計喉癌術後感染者的跼部複髮率，分析喉癌術後感染與跼部腫瘤複髮的相關性。結果160例喉癌手術患者中髮生感染共30例，感染率為18.75%；術後感染部位主要是切口，其次分彆為呼吸道和嚥部等。30例術後感染者中共分離齣27株病原菌，其中革蘭暘性菌12株（44.44%），革蘭陰性菌15株（55.56%）。多因素分析顯示，手術時間、臨床分期和全喉切除術是導緻喉癌術後感染的主要危險因素（P均＜0.05）。術後隨訪6箇月，160例患者中有18例跼部複髮，複髮率為11.25%；其中術後感染者跼部複髮8例，複髮率26.67%（8/30）；無感染者術後跼部複髮率為7.69%（10/130），兩組相比差異具有統計學意義（χ2=12.659、P=0.000）。結論導緻喉癌術後感染的主要危險因素為手術時間、臨床分期和手術類型；術後感染者跼部腫瘤複髮率更高。
목적：분석후암술후감염상관인소급여국부종류복발적상관성。방법회고성분석우본원행수술치료적160례후암환자적림상자료，기록술후감염적부위급병원균충류；채용Logistic회귀방정계산후암술후감염고위인소。통계후암술후감염자적국부복발솔，분석후암술후감염여국부종류복발적상관성。결과160례후암수술환자중발생감염공30례，감염솔위18.75%；술후감염부위주요시절구，기차분별위호흡도화인부등。30례술후감염자중공분리출27주병원균，기중혁란양성균12주（44.44%），혁란음성균15주（55.56%）。다인소분석현시，수술시간、림상분기화전후절제술시도치후암술후감염적주요위험인소（P균＜0.05）。술후수방6개월，160례환자중유18례국부복발，복발솔위11.25%；기중술후감염자국부복발8례，복발솔26.67%（8/30）；무감염자술후국부복발솔위7.69%（10/130），량조상비차이구유통계학의의（χ2=12.659、P=0.000）。결론도치후암술후감염적주요위험인소위수술시간、림상분기화수술류형；술후감염자국부종류복발솔경고。
Objective To analyze the factors of the postoperative infection in laryngeal cancer and its relationship with the local tumor recurrence. Methods The clinical data of 160 cases of laryngeal carcinoma patients treated in our hosptial were analyzed, retrospectively, while the location and pathogens occurred postoperative infection were analyzed. The risk factors were calculated by Logistic regression equation. Local recurrence rate of postoperative infection was laryngeal statistics, correlation of laryngeal postoperative infection and local recurrence were analyzed, respectively. Results Among the 160 laryngeal cancer patients with operation, there were 30 cases with infection, with the infection rate of 18.75%. The main postoperative incision site infection was incision, and then were respiratory system, pharynx. There were 27 strains of pathogenic bacteria were isolated from 30 cases with postoperative infection, included 12 (44.44%) strains of Gram positive, 15 (55.56%) strains of Gram negative. The multivariate analysis showed that the operation time, clinical stage and total laryngectomy were the main risk factors of postoperative infection cause laryngeal cancer (P all<0.05). Patients were followed up for 6 months, among 160 cases, there were 18 cases with local recurrence, with the recurrence rate of 11.25%. Local recurrence in patients with postoperative infection in 8 cases, with the recurrence rate of 26.67%(8/30);no infection of patients with postoperative local, with the recurrence rate of 7.69%(10/130), with significant differences (χ2=12.659, P=0.000). Conclusions The major risk factors caused laryngeal cancer postoperative infection were operation time, clinical staging and operation type. The recurrence rate of patients with postoperative infection tumor was higher.
