CAJ | 학술논문

目的：探讨莆田地区畲族健康人群骨密度与骨生化指标、睾酮以及雌二醇之间的关系，并与汉族人群比较，为本地区骨质疏松防治提供依据。方法选择本地区畲族聚集地40岁以上健康成年人，其中畲族532人，汉族563人，应用美国Osteometer Medi Tech公司生产的DTX-200骨密度吸收仪检测骨密度，以及用罗氏公司的骨生化指标仪器及试剂盒，测量骨密度以及25羟维生素D（25（OH）D3）、骨钙素（BGP）、雌二醇（E2）、睾酮（T）、甲状旁腺激素（PTH）、1型前胶原氨基末端肽（P1NP）、碱性磷酸酶（ALP）。把上述检测的数据结果输入电脑，应用SPSS17.0软件包进行数据分析。结果不管畲族和汉族的骨密度均随着年龄的增大而下降，同年龄段男性均高于女性。畲族女性除在40～49岁年龄段稍高于汉族外，其他年龄组汉族女性均高于畲族。而畲族男性在60～69岁年龄段稍高于汉族男性，其他年龄组汉族男性均高于畲族，但汉族与畲族间都没有显著性差异（P＞0.05）。汉族的25（OH）D3明显高于畲族，尤其女性在40～60岁年龄段、男性在50～69岁年龄段为正相关（P＜0.05）；汉族的BGP高于畲族（P＜0.05），汉族男的E2指标均高于畲族男，且40～59年龄段尤为明显（P＜0.05）。P1NP在汉族男女性高于畲族男女性（P＜0.05）。经皮尔森相关分析，骨密度与E2、25OHD3、T成正相关，而与PTH、BGP、ALP成负相关，与ALP无相关。结论本研究25（OH）D3、BGP、P1NP、E2测定可以作为汉族、畲族健康人群早期检测指标，畲族的25（OH）D3水平普遍偏低，可能与他们的生活方式或者维生素D基因有关，值得进一步研究。骨密度与25（OH）D3、E2、T有明显正相关，而与PTH、PINP、BCG负相关，与ALP无明显相关。
목적：탐토보전지구여족건강인군골밀도여골생화지표、고동이급자이순지간적관계，병여한족인군비교，위본지구골질소송방치제공의거。방법선택본지구여족취집지40세이상건강성년인，기중여족532인，한족563인，응용미국Osteometer Medi Tech공사생산적DTX-200골밀도흡수의검측골밀도，이급용라씨공사적골생화지표의기급시제합，측량골밀도이급25간유생소D（25（OH）D3）、골개소（BGP）、자이순（E2）、고동（T）、갑상방선격소（PTH）、1형전효원안기말단태（P1NP）、감성린산매（ALP）。파상술검측적수거결과수입전뇌，응용SPSS17.0연건포진행수거분석。결과불관여족화한족적골밀도균수착년령적증대이하강，동년령단남성균고우녀성。여족녀성제재40～49세년령단초고우한족외，기타년령조한족녀성균고우여족。이여족남성재60～69세년령단초고우한족남성，기타년령조한족남성균고우여족，단한족여여족간도몰유현저성차이（P＞0.05）。한족적25（OH）D3명현고우여족，우기녀성재40～60세년령단、남성재50～69세년령단위정상관（P＜0.05）；한족적BGP고우여족（P＜0.05），한족남적E2지표균고우여족남，차40～59년령단우위명현（P＜0.05）。P1NP재한족남녀성고우여족남녀성（P＜0.05）。경피이삼상관분석，골밀도여E2、25OHD3、T성정상관，이여PTH、BGP、ALP성부상관，여ALP무상관。결론본연구25（OH）D3、BGP、P1NP、E2측정가이작위한족、여족건강인군조기검측지표，여족적25（OH）D3수평보편편저，가능여타문적생활방식혹자유생소D기인유관，치득진일보연구。골밀도여25（OH）D3、E2、T유명현정상관，이여PTH、PINP、BCG부상관，여ALP무명현상관。
Objective To explore the relationship of bone mineral density ( BMD ) with bone biochemical markers and testosterone and estradiol of Chinese She-zu in Putian, and compare with the Han-zu, in order to provide the basis for prevention and treatment of osteoporosis in this region.Methods The healthy adults over 40 years old of Chinese She-zu from the gathering place, including the Chinese She-zu 532 and Chinese Han 563 were selected.By DTX-200 BMD absorptiometry, the BMD were detected.BMD,25(OH)D3,BGP,E2,T,PTH,P1NP and ALP were measured.The date were analyzed with SPSS17.0 software. Results The BMD of She-zu or Han-zu decreased with age, the BMD of men were higher than women in same age.The BMD of women of Han-zu were higher than She-zu in same age except the age of 40~49, the BMD of men of Han-zu were higher than She-zu in same age apart from the age of 60~69.There were no significant differences between Han-zu and She-zu(P<0.05).BMD were positively correlated with E2, 25(OH)D3 and T,and were negatively correlated with BGP, ALP.25(OH)D3 of Han-zu were significantly higher than She-zu, especially women in the 40~60 age and men in the 50~69 age.BGP of Han were higher than She-zu (P <0.05), The E2 of Han male were higher than She-zu male, especially 40~59 age group (P <0.05).P1NP of Han were higher than She-zu ( P <0.05 ) .The Pearson correlation analysis showed that BMD were positively correlated with E2 , 25OHD3 and T, and negatively correlatied with PTH, BGP, ALP.Conclusions The study of 25(OH)D3, BGP, P1NP, E2 can be used as early detection targets for the Han-zu, She-zu healthy people, 25 ( OH) D3 levels of She-zu generally are low, this may be related to their lifestyle or vitamin D gene.BMD are positively correlated with 25 ( OH) D3 , E2 and T significantly, negatively correlated with PTH, PINP, BCG, and not correlated with ALP.