CAJ | 학술논문

目的：研发一种用于治疗骨质疏松椎体压缩骨折的新型复合生物玻璃的磷酸钙骨水泥，并观察其体外材料学及生物学活性。方法将不同质量百分比的生物玻璃（ bioglass，BG）与磷酸钙（ calcium phosphate cement，CPC ）球磨后物理共混获得一种具有可注射、自固化、可降解的椎体成型替代材料。分别对该替代材料的凝固时间、流动性、力学强度进行测定并行材料体外成骨细胞粘附实验、增殖实验，观察其生物相容性。结果随着新型替代材料中BG组分含量的增加，替代材料的凝固时间逐渐延长，同时，流动性较磷酸钙骨水泥改善明显。随着凝固时间的延长，替代材料固化后的抗压强度显著高于实验组CPC骨水泥。此外，与CPC相比，替代材料更有利于细胞的粘附、增殖及分化，具有良好的生物相容性。结论新型复合生物玻璃的磷酸钙的生物材料不仅具有可注射性和较高的力学强度，同时骨传导性能更好，有希望成为临床治疗骨质疏松椎体压缩骨折的一种新型椎体成形材料。
목적：연발일충용우치료골질소송추체압축골절적신형복합생물파리적린산개골수니，병관찰기체외재료학급생물학활성。방법장불동질량백분비적생물파리（ bioglass，BG）여린산개（ calcium phosphate cement，CPC ）구마후물리공혼획득일충구유가주사、자고화、가강해적추체성형체대재료。분별대해체대재료적응고시간、류동성、역학강도진행측정병행재료체외성골세포점부실험、증식실험，관찰기생물상용성。결과수착신형체대재료중BG조분함량적증가，체대재료적응고시간축점연장，동시，류동성교린산개골수니개선명현。수착응고시간적연장，체대재료고화후적항압강도현저고우실험조CPC골수니。차외，여CPC상비，체대재료경유리우세포적점부、증식급분화，구유량호적생물상용성。결론신형복합생물파리적린산개적생물재료불부구유가주사성화교고적역학강도，동시골전도성능경호，유희망성위림상치료골질소송추체압축골절적일충신형추체성형재료。
Objective To develop a new type of bone cements by adding bioglass ( BG) into calcium phosphate cement ( CPC) and evaluate its material properties and bioactivity.Methods Different proportions of the CPC-BG composite were mixed to obtain an injectable, self-solidified, and degradable alternative material.The osteoblasts ( OB) were seeded onto the CPC-BG composite disks and the adhesion, proliferation, morphology, and differentiation abilities of the OB were observed.Results The setting times of CPC-BG were prolonged as the content of BG increased.The injectability of CPC-BG composite paste improved significantly compared to that of CPC paste ( P<0.05) .The compressive strength of CPC-BG composites was higher than that of CPC significantly ( P<0.05 ) .In addition, the degree of cell attachment, proliferation and differentiation, and biocompatibility increased by adding BG into CPC.Conclusion CPC-BG with injectability and high strength and good bioactivity, may become a new material for vertebroplasy in the treatment of osteoporotic compressive fractures.