疑难病杂志
疑難病雜誌
의난병잡지
JOURNAL OF DIFFICULT AND COMPLICATED CASES
2015年
9期
881-883,887
,共4页
高血压%左心室肥厚%氨氯地平%复方盐酸阿米洛利%通心络胶囊%心脏结构%心功能
高血壓%左心室肥厚%氨氯地平%複方鹽痠阿米洛利%通心絡膠囊%心髒結構%心功能
고혈압%좌심실비후%안록지평%복방염산아미락리%통심락효낭%심장결구%심공능
Hypertension%Left ventricular hypertrophy%Amlodipine%Compound amiloride hydrochloride%Tongxinluo capsule%Cardiac structure%Heart function
目的：比较氨氯地平＋复方盐酸阿米洛利与氨氯地平＋复方盐酸阿米洛利＋通心络胶囊治疗高血压伴有左室肥厚（ LVH）患者的效果。方法将确诊的82例高血压伴LVH患者随机按数字表法以3∶2分为常规组（48例）和通心络组（34例）。常规组给予氨氯地辛＋复方盐阿米洛利；通心络组在常规组基础上加通心络。治疗6个月后，观察2组患者心脏结构、心功能及血压水平的变化情况。结果常规组及通心络组患者经过治疗后，收缩压（SBP）、舒张压（DBP）、室间隔厚度（IVST）、左室后壁厚度（LVPWT）、左室重量（LVM）、左室重量指数（LVMI）与治疗前比较，均有显著降低（ P ＜00．1）；E／A比值及LVEF 值与治疗前比较均有显著升高（ P ＜0．05）；2组间治疗后收缩压、舒张压差异无统计学意义（ P ＞0．05），但2组间IVST[（9．60±2．48）mm vs．（8．80±1．23）mm]、LVPWT[（9．39±1．20）mm vs．（8．07±1．40）mm]、LVM[（275．11±14．77）g vs．（271．02±16．25）g]、LVMI[（150．99±7．35）g／m2 vs．（147．02±8．88）g／m2]、E／A（0．73±0．18 vs．0．78±0．24）、LVEF [（65．28±3．15）％vs．（66．32±3．12）％]比较差异均有统计学意义（ P ＜0．05），通心络组改善更明显。结论通心络胶囊联用氨氯地平＋复方盐酸阿米洛利具有提高左室射血分数、改善心功能，从而达到延缓和／或逆转左室肥厚的功效。
目的：比較氨氯地平＋複方鹽痠阿米洛利與氨氯地平＋複方鹽痠阿米洛利＋通心絡膠囊治療高血壓伴有左室肥厚（ LVH）患者的效果。方法將確診的82例高血壓伴LVH患者隨機按數字錶法以3∶2分為常規組（48例）和通心絡組（34例）。常規組給予氨氯地辛＋複方鹽阿米洛利；通心絡組在常規組基礎上加通心絡。治療6箇月後，觀察2組患者心髒結構、心功能及血壓水平的變化情況。結果常規組及通心絡組患者經過治療後，收縮壓（SBP）、舒張壓（DBP）、室間隔厚度（IVST）、左室後壁厚度（LVPWT）、左室重量（LVM）、左室重量指數（LVMI）與治療前比較，均有顯著降低（ P ＜00．1）；E／A比值及LVEF 值與治療前比較均有顯著升高（ P ＜0．05）；2組間治療後收縮壓、舒張壓差異無統計學意義（ P ＞0．05），但2組間IVST[（9．60±2．48）mm vs．（8．80±1．23）mm]、LVPWT[（9．39±1．20）mm vs．（8．07±1．40）mm]、LVM[（275．11±14．77）g vs．（271．02±16．25）g]、LVMI[（150．99±7．35）g／m2 vs．（147．02±8．88）g／m2]、E／A（0．73±0．18 vs．0．78±0．24）、LVEF [（65．28±3．15）％vs．（66．32±3．12）％]比較差異均有統計學意義（ P ＜0．05），通心絡組改善更明顯。結論通心絡膠囊聯用氨氯地平＋複方鹽痠阿米洛利具有提高左室射血分數、改善心功能，從而達到延緩和／或逆轉左室肥厚的功效。
목적：비교안록지평＋복방염산아미락리여안록지평＋복방염산아미락리＋통심락효낭치료고혈압반유좌실비후（ LVH）환자적효과。방법장학진적82례고혈압반LVH환자수궤안수자표법이3∶2분위상규조（48례）화통심락조（34례）。상규조급여안록지신＋복방염아미락리；통심락조재상규조기출상가통심락。치료6개월후，관찰2조환자심장결구、심공능급혈압수평적변화정황。결과상규조급통심락조환자경과치료후，수축압（SBP）、서장압（DBP）、실간격후도（IVST）、좌실후벽후도（LVPWT）、좌실중량（LVM）、좌실중량지수（LVMI）여치료전비교，균유현저강저（ P ＜00．1）；E／A비치급LVEF 치여치료전비교균유현저승고（ P ＜0．05）；2조간치료후수축압、서장압차이무통계학의의（ P ＞0．05），단2조간IVST[（9．60±2．48）mm vs．（8．80±1．23）mm]、LVPWT[（9．39±1．20）mm vs．（8．07±1．40）mm]、LVM[（275．11±14．77）g vs．（271．02±16．25）g]、LVMI[（150．99±7．35）g／m2 vs．（147．02±8．88）g／m2]、E／A（0．73±0．18 vs．0．78±0．24）、LVEF [（65．28±3．15）％vs．（66．32±3．12）％]비교차이균유통계학의의（ P ＜0．05），통심락조개선경명현。결론통심락효낭련용안록지평＋복방염산아미락리구유제고좌실사혈분수、개선심공능，종이체도연완화／혹역전좌실비후적공효。
Objective To compare the therapeutic effect of amlodipine +compound amiloride hydrochloride and am-lodipine +compound amiloride +Tongxinluo capsule for treating of hypertension associated with left ventricular hypertrophy . Methods Eighty-two patients with LVH were divided into conventional group ( 48 cases) , and Tongxinluo group ( 34 ca-ses), they were given routine amlodipine +compound amiloride;Tongxinluo capsule group based on the conventional thera-py, also added Tongxinluo capsule(1.14g once ,three times a day).After 6 months of treatment, cardiac structure and heart function and changes in blood pressure levels in the two groups were observed .Resutl s After treatment , conventional group and Tongxinluo group patients’ systolic blood pressure (SBP), diastolic blood pressure (DBP), inter-ventricular septum thickness ( IVST ) , left ventricular wall thickness ( LVPWT ) , left ventricular weight ( LVM ) , left ventricular mass index (LVMI) were significantly decreased compared with before treatment ( P <0.01);E /A ratio and LVEF values?were sig-nificantly increased than before treatment ( P <0.05);after treatment, between the two groups, systolic blood pressure, di-astolic blood pressure’s difference were not statistically significant ( P >0.05), but IVST [(9.60 ±2.48) min vs.(8.80 ± 1.23) min],LVPWT [(9.39 ±1.20) min vs.(8.07 ±1.40) min],LVM [(275.11 ±14.77) g vs.(271.02 ±16.25) g],LVMI[( 1509.9 ±7 .35) g /m2 vs.(147.02 ±8.88) g/m2 ],E/A (0.75 ±0.18 vs.0.78 ±0.24), LVEF [(65.28 ± 3.15)%vs .(66.32 ±3.12)%]’ s differences in the 2 groups were statistically significant ( P <0.05 ), the Tongxinluo group improved more obviously .Conclusion Tongxinl uo capsule combined with amlodipine +compound amiloride hydro-chloride can increase left ventricular ejection fraction , improving heart function , so as to delay ando/r reverse left ventricular hypertrophy .
