CAJ | 학술논문

目的：研究类风湿关节炎（rheumatoid arthritis，RA）患者血清肿瘤标记物水平与其病情活动度及肿瘤发生的相关性。方法统计RA患者35例，健康对照个体31例，均进行血清肿瘤标志物CEA、CA125水平测定，并对RA组患者进行CRP、ESR测定及DAS28评分。对两组患者血清肿瘤标志物水平及阳性率进行比较，对RA组血清肿瘤标志物水平与CRP、ESR及DAS28评分进行相关性分析。对两组肿瘤阳性率进行比较。采用ι检验，χ2检验，Spearman相关系数进行统计学分析。结果RA组患者血清CEA、CA125、水平及阳性率高于正常对照组（ P＜0.05），其中血清CEA、CA125水平与ESR、CRP及DAS28评分呈正相关（P均＜0.05）。 RA组患者肿瘤发生率与正常组无显著差别（P＞0.05）。结论 RA患者血清肿瘤标志物CEA及CA125水平及阳性率升高，与疾病活动有关，但肿瘤阳性率未升高，故血清CEA及CA125水平可作为评估RA患者疾病活动度的参考指标之一。
목적：연구류풍습관절염（rheumatoid arthritis，RA）환자혈청종류표기물수평여기병정활동도급종류발생적상관성。방법통계RA환자35례，건강대조개체31례，균진행혈청종류표지물CEA、CA125수평측정，병대RA조환자진행CRP、ESR측정급DAS28평분。대량조환자혈청종류표지물수평급양성솔진행비교，대RA조혈청종류표지물수평여CRP、ESR급DAS28평분진행상관성분석。대량조종류양성솔진행비교。채용ι검험，χ2검험，Spearman상관계수진행통계학분석。결과RA조환자혈청CEA、CA125、수평급양성솔고우정상대조조（ P＜0.05），기중혈청CEA、CA125수평여ESR、CRP급DAS28평분정정상관（P균＜0.05）。 RA조환자종류발생솔여정상조무현저차별（P＞0.05）。결론 RA환자혈청종류표지물CEA급CA125수평급양성솔승고，여질병활동유관，단종류양성솔미승고，고혈청CEA급CA125수평가작위평고RA환자질병활동도적삼고지표지일。
Objective To identify the serum CEA and CA125 levels in rheumatoid arthritis ( RA) patients and their association with the characteristics of the tumor.Methods Serum levels of CEA and CA125 in 35 RA patients and 31 healthy controls were detected.ESR and CRP were detected and the disease activity was assessed by DAS28 score in RA group.The difference of serum levels of CEA and CA125 between RA group and healthy control group was compared.The association between the serum CEA and CA125 levels and ESR, CRP, and DAS28 score was further revealed.The difference of the occurrence of cancers between RA group and healthy control group was compared.T test, χ2 test, and Spearman rank correlation were used for statistical analysis. Results Serum levels and positive rates of tumor markers CEA and CA125 were significantly increased in RA group compared to those in healthy control group ( P<0.05) .The serum levels of CEA and CA125 had a positive correlation with the levels of ESR, CRP, and DAS28 score in RA group ( P<0.05 ) .There was no significant difference in the occurrence of cancers between RA group and healthy control group ( P<0.05 ) .Conclusion The serum concentrations of CEA and CA125 in RA group increase significantly but the occurrence of cancers does not increase.The tumor markers CEA and CA125 may play a role in evaluating the disease activity of RA.