中华肝脏病杂志
中華肝髒病雜誌
중화간장병잡지
CHINESE JOURNAL OF HEPATOLOGY
2015年
8期
586-589
,共4页
邓勇%吴维新%张大志%胡鹏%康娟%杨轶轩%曾维琼
鄧勇%吳維新%張大誌%鬍鵬%康娟%楊軼軒%曾維瓊
산용%오유신%장대지%호붕%강연%양질헌%증유경
肝炎病毒,乙型%抗病毒药%替比夫定
肝炎病毒,乙型%抗病毒藥%替比伕定
간염병독,을형%항병독약%체비부정
Hepatitis B virus%Antiviral agents%Telbivudine
目的 观察替比夫定阻断HBV DNA高载量孕妇宫内传播的效果及停药后的安全性.方法 收集慢性HBV携带者且孕周24 ~ 30周孕妇资料,HBV DNA均≥1×106IU/ml;根据患者意愿将其分为“替比夫定治疗组”和“对照组”,替比夫定治疗组在孕妇孕26周时,给予替比夫定600 mg/d口服抗病毒治疗至产后1个月停用,对照组患者不用抗病毒药物.两组孕妇均接受剖宫产术,新生儿产后均接受主、被动联合免疫,出生后12h内注射乙型肝炎免疫球蛋白200 IU及0、1、6个月注射乙型肝炎疫苗20 μ g.禁止母乳喂养.计量资料比较用t检验,计数资料比较用x2检验. 结果 共收集157例HBV携带者孕妇资料,替比夫定治疗组82例,对照组75例,年龄20 ~ 40岁.替比夫定治疗组孕妇HBV DNA在产前下降均>210g10,有效率为100%,至分娩前替比夫定治疗组有16例HBV DNA转阴,转阴率为19.5% (16/82),而对照组无转阴,两组比较,差异有统计学意义(P<0.05).两组新生儿及随访婴儿至6个月,替比夫定治疗组婴儿HBsAg、HBV DNA阳性率均为0,对照组婴儿HBsAg、HBV DNA阳性率均为5.3%,替比夫定治疗组与对照组HBV母婴传播的阻断率分别为100%和94.7%,两组比较,差异均有统计学意义(P值均<0.05).替比夫定治疗组停药后随访至产后6个月,HBV DNA:(1.79× 107±4.20× 107) IU/ml,ALT:(31.72±9.89) U/L,AST:(31.49±9.93) U/L.两组均未发现有不良反应或先天性畸形.结论 HBV DNA高滴度孕妇妊娠中晚期应用替比夫定抗病毒治疗能明显降低孕妇外周血HBV DNA载量,阻断HBV宫内传播,且近期疗效、耐受性和安全性良好.肝生物化学指标正常孕妇短程服用替比夫定停药后安全性好.
目的 觀察替比伕定阻斷HBV DNA高載量孕婦宮內傳播的效果及停藥後的安全性.方法 收集慢性HBV攜帶者且孕週24 ~ 30週孕婦資料,HBV DNA均≥1×106IU/ml;根據患者意願將其分為“替比伕定治療組”和“對照組”,替比伕定治療組在孕婦孕26週時,給予替比伕定600 mg/d口服抗病毒治療至產後1箇月停用,對照組患者不用抗病毒藥物.兩組孕婦均接受剖宮產術,新生兒產後均接受主、被動聯閤免疫,齣生後12h內註射乙型肝炎免疫毬蛋白200 IU及0、1、6箇月註射乙型肝炎疫苗20 μ g.禁止母乳餵養.計量資料比較用t檢驗,計數資料比較用x2檢驗. 結果 共收集157例HBV攜帶者孕婦資料,替比伕定治療組82例,對照組75例,年齡20 ~ 40歲.替比伕定治療組孕婦HBV DNA在產前下降均>210g10,有效率為100%,至分娩前替比伕定治療組有16例HBV DNA轉陰,轉陰率為19.5% (16/82),而對照組無轉陰,兩組比較,差異有統計學意義(P<0.05).兩組新生兒及隨訪嬰兒至6箇月,替比伕定治療組嬰兒HBsAg、HBV DNA暘性率均為0,對照組嬰兒HBsAg、HBV DNA暘性率均為5.3%,替比伕定治療組與對照組HBV母嬰傳播的阻斷率分彆為100%和94.7%,兩組比較,差異均有統計學意義(P值均<0.05).替比伕定治療組停藥後隨訪至產後6箇月,HBV DNA:(1.79× 107±4.20× 107) IU/ml,ALT:(31.72±9.89) U/L,AST:(31.49±9.93) U/L.兩組均未髮現有不良反應或先天性畸形.結論 HBV DNA高滴度孕婦妊娠中晚期應用替比伕定抗病毒治療能明顯降低孕婦外週血HBV DNA載量,阻斷HBV宮內傳播,且近期療效、耐受性和安全性良好.肝生物化學指標正常孕婦短程服用替比伕定停藥後安全性好.
목적 관찰체비부정조단HBV DNA고재량잉부궁내전파적효과급정약후적안전성.방법 수집만성HBV휴대자차잉주24 ~ 30주잉부자료,HBV DNA균≥1×106IU/ml;근거환자의원장기분위“체비부정치료조”화“대조조”,체비부정치료조재잉부잉26주시,급여체비부정600 mg/d구복항병독치료지산후1개월정용,대조조환자불용항병독약물.량조잉부균접수부궁산술,신생인산후균접수주、피동연합면역,출생후12h내주사을형간염면역구단백200 IU급0、1、6개월주사을형간염역묘20 μ g.금지모유위양.계량자료비교용t검험,계수자료비교용x2검험. 결과 공수집157례HBV휴대자잉부자료,체비부정치료조82례,대조조75례,년령20 ~ 40세.체비부정치료조잉부HBV DNA재산전하강균>210g10,유효솔위100%,지분면전체비부정치료조유16례HBV DNA전음,전음솔위19.5% (16/82),이대조조무전음,량조비교,차이유통계학의의(P<0.05).량조신생인급수방영인지6개월,체비부정치료조영인HBsAg、HBV DNA양성솔균위0,대조조영인HBsAg、HBV DNA양성솔균위5.3%,체비부정치료조여대조조HBV모영전파적조단솔분별위100%화94.7%,량조비교,차이균유통계학의의(P치균<0.05).체비부정치료조정약후수방지산후6개월,HBV DNA:(1.79× 107±4.20× 107) IU/ml,ALT:(31.72±9.89) U/L,AST:(31.49±9.93) U/L.량조균미발현유불량반응혹선천성기형.결론 HBV DNA고적도잉부임신중만기응용체비부정항병독치료능명현강저잉부외주혈HBV DNA재량,조단HBV궁내전파,차근기료효、내수성화안전성량호.간생물화학지표정상잉부단정복용체비부정정약후안전성호.
Objective To determine the efficacy and safety oftelbivudine for blocking intrauterine transmission of hepatitis B virus (HBV) in pregnant women with high-load HBV DNA.Methods Women in general good health and pragnant were enrolled for study between the ages of 20 to 40 year-old,with a diagnosis of HBV infection with high-load HBV DNA level (≥ 1×106IU / ml).According to each participant's willingness,the women were divided into a telbivudine treatment group (82 women) and an untreated control group (75 women).The telbivudine treatment was initiated at gestation week 26 as oral dosing of 600 mg/d and continued until 1 month after the birth.Women in the control group had not gotten any antiviral drug treatment.All of the women delivered by cesarean section,and all of the neonates were administered the standard passive immunization therapy,which consisted of a hepatitis B immunoglobulin (200 1U) injection given within 12 hours of birth and an injection of hepatitis B vaccine (20 μg) at birth and at postnatal month 1 and 6.None of the mother's performed breastfeeding.Results The telbivudine-treated women showed a significant decrease in HBV DNA levels prior to delivery,as well as significantly decreased prenatal HBV DNA levels (>2 logl0).Efficiency of the telbivudine treatment was 100%.Immediately prior to delivery,16 (19.5%) of the women in the telbivudine treatment group showed negative HBV DNA status,as opposed to the untreated control group in which no women showed negative status.The telbivudine treatment group had no case of maternal or fetal adverse reaction or of congenital malf ormation.Conclusion Use of telbivudine antiviral therapy during late pregnancy in women with high-load HBV DNA can significantly reduce level of HBV DNA in maternal peripheral blood,block HBV intrauterine transmission,and provide good short-term efficacy,with good tolerability and safety.