CAJ | 학술논문

目的：探讨肺癌合并静脉血栓患者的临床特点及预后。方法120例肺癌合并静脉血栓患者，分析患者的一般资料、静脉血栓发生的部位、症状及治疗情况；统计确诊肺癌后3、6、9、12个月及以后发生血栓的情况。结果肺血栓栓塞组中，确诊肺癌后3、6、9、12个月及12个月以后出现血栓栓塞例数分别为36、40、44、45、52例，静脉血栓栓塞组则分别为51、53、54、55、68例，比较差异无统计学意义(P>0.05)。化疗组在3、6、9、12个月及12个月以后出现血栓例数分别为28、36、39、39、48例，而手术组分别为21、25、25、25、28例，比较差异无统计学意义(P>0.05)。诊断静脉血栓栓塞后3、6、9、12个月及12个月后的累计死亡例数，肺血栓栓塞组分别为22、30、33、33、39例，而静脉血栓栓塞组分别为17、24、28、30、40例，差异无统计学意义(P>0.05)。结论肺癌患者静脉血栓栓塞的发生率较高，确诊后3~6个月是高发期；合并静脉血栓栓塞的肺癌患者病死率较高，大多数在1年内死亡，积极的预防、治疗静脉血栓栓塞对于延长肺癌患者生存期有重要的意义。
목적：탐토폐암합병정맥혈전환자적림상특점급예후。방법120례폐암합병정맥혈전환자，분석환자적일반자료、정맥혈전발생적부위、증상급치료정황；통계학진폐암후3、6、9、12개월급이후발생혈전적정황。결과폐혈전전새조중，학진폐암후3、6、9、12개월급12개월이후출현혈전전새례수분별위36、40、44、45、52례，정맥혈전전새조칙분별위51、53、54、55、68례，비교차이무통계학의의(P>0.05)。화료조재3、6、9、12개월급12개월이후출현혈전례수분별위28、36、39、39、48례，이수술조분별위21、25、25、25、28례，비교차이무통계학의의(P>0.05)。진단정맥혈전전새후3、6、9、12개월급12개월후적루계사망례수，폐혈전전새조분별위22、30、33、33、39례，이정맥혈전전새조분별위17、24、28、30、40례，차이무통계학의의(P>0.05)。결론폐암환자정맥혈전전새적발생솔교고，학진후3~6개월시고발기；합병정맥혈전전새적폐암환자병사솔교고，대다수재1년내사망，적겁적예방、치료정맥혈전전새대우연장폐암환자생존기유중요적의의。
Objective To investigate clinical characteristics and prognosis of lung cancer complicated with phlebothrombosis. Methods Analysis was made on general data, location of phlebothrombosis, symptoms and treatment status in 120 lung cancer complicated with phlebothrombosis patients. Occurrence of thrombus was summarized in 3, 6, 9, 12 months after diagnosis of lung cancer. Results In the pulmonary thromboembolism group, there were respectively 36, 40, 44, 45, 52 cases with thromboembolism after 3, 6, 9, 12, and over 12 months of diagnosis of lung cancer. Those numbers in the venous thromboembolism group were 51, 53, 54, 55, 68 cases. Their differences had no statistical significance (P>0.05). In the chemotherapy group, there were respectively 28, 36, 39, 39, 48 cases with thromboembolism after 3, 6, 9, 12, and over 12 months of diagnosis of lung cancer. Those numbers in the operation group were 21, 25, 25, 25, 28 cases. Their differences had no statistical significance (P>0.05). Pulmonary thromboembolism group had death cases as in 22, 30, 33, 33, 39 cases after 3, 6, 9, 12, and over 12 months of diagnosis of venous thromboembolism. Those numbers of venous thromboembolism group were 17, 24, 28, 30, 40 cases. Their differences had no statistical significance (P>0.05). Conclusion Lung cancer patients have high incidence of venous thromboembolism, which has its high-incidence period in 3~6 months after diagnosis. Those patients of lung cancer complicated with venous thromboembolism have high mortality rate, and most of them die within 1 year. Active prevention and treatment of venous thromboembolism contain important significance for prolonging life time of lung cancer patients.